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Updated: Sep 12, 2025

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
Infertility Due to a Novel Variant of a Balanced Y;1 Translocation: A Case Report
Somer Magnuson1, Kasey Doney1, Logan B Wesemann1
1Urology, Rocky Vista University College of Osteopathic Medicine, Ivins, USA.
None:
This report describes a 26-year-old male presenting with primary infertility due to severe cryptozoospermia. Diagnostic evaluation revealed a novel balanced translocation at 46,X, t(Y;1)(q11.21,p32.1) and heterozygote carrier status for dysferlinopathy (DYSF). The patient's hormonal profile was normal, and Y chromosome microdeletion testing was negative. Despite testicular sperm aspiration (TESA) and two rounds of in vitro fertilization (IVF) with intracytoplasmic sperm injection (ICSI), fertilization and embryo development were poor. This case highlights the challenges in diagnosing and treating male infertility associated with rare Y;1 translocations and emphasizes the need for further research to improve management strategies.
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