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Diagnostic value of lnc-RNAs TINCR, GC1 and AFAP1-AS1 in gastric cancer differentiation from healthy people

  • 0Student Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Biomarkers in Medicine +

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August 5, 2025

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August 5, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

This study identifies specific long non-coding RNAs (lncRNAs) as promising biomarkers for early gastric cancer detection. These novel lncRNAs show significant diagnostic potential in patients compared to healthy individuals.

Area Of Science

  • Oncology
  • Molecular Biology
  • Biomarker Discovery

Background

  • Gastric cancer poses a global health challenge, highlighting the need for improved diagnostic methods.
  • Current diagnostic tools require enhancement, driving research into novel biomarkers.
  • Long non-coding RNAs (lncRNAs) are increasingly recognized for their roles in various diseases, including cancer.

Purpose Of The Study

  • To investigate the diagnostic potential of a panel of lncRNAs in gastric cancer.
  • To compare the expression levels of selected lncRNAs in gastric cancer patients versus healthy controls.
  • To evaluate the utility of lncRNAs as non-invasive biomarkers for gastric cancer diagnosis.

Main Methods

  • A retrospective case-control study involving 256 participants (128 gastric cancer patients, 128 healthy controls).
  • Serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19.9) were measured.
  • Plasma expression profiling of eight lncRNAs was performed using selected samples.

Main Results

  • Significant alterations in CEA and CA19.9 levels were observed in gastric cancer patients (p < 0.05).
  • Upregulated expression of HOTIP, BANCR, ZFAS1, TINCR, GC1, and AFAP1-AS1 lncRNAs was found in gastric cancer patients (p < 0.05).
  • ROC curve analysis indicated diagnostic potential for these lncRNAs in gastric cancer detection, demonstrating notable specificity and sensitivity.

Conclusions

  • Plasma HOTIP, BANCR, ZFAS1, TINCR, GC1, and AFAP1-AS1 lncRNAs serve as valuable diagnostic biomarkers for gastric cancer.
  • Dysregulated lncRNAs offer promising avenues for the non-invasive diagnostic assessment of gastric cancer.
  • These findings contribute to the development of novel strategies for early gastric cancer detection.

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