Related Experiment Video
Updated: Sep 12, 2025

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
Published on: May 26, 2019
Inherent Weakly Coordinating Oxo-Group-Directed Ruthenium(II)-Catalyzed C5 Functionalization of
Tarun Jangir1, Dhananjay S Nipate1, Vani Dhyani1
1Department of Chemistry, Birla Institute of Technology and Science, Pilani, Pilani Campus, Vidya Vihar, Pilani, Rajasthan 333031, India.
Abstract:
A Ru(II)-catalyzed inherent weakly coordinating oxo-group-directed site-selective C5 functionalization of 2-arylquinolin-4(1H)-ones using various coupling partners like allyl alcohols, acrylates, styrenes, maleimides, and acrylamide has been described. The developed method allowed the synthesis of C5-substituted 2-arylquinolin-4(1H)-ones in good to excellent yields. The protocol is compatible with a broad range of functional groups and can be used on the gram scale. In addition, based on the control experiments, a plausible reaction mechanism has been proposed for this transformation.
More Related Videos
06:34Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
Published on: June 20, 2014
10:51The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
Related Concept Videos
ortho–para-Directing Activators: –CH3, –OH, –⁠NH2, –OCH3
Oxidation of Phenols to Quinones
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Mechanism
Cyclohexenones via Michael Addition and Aldol Condensation: The Robinson Annulation
Diazonium Group Substitution: –OH and –H
Preparation of 1° Amines: Hofmann and Curtius Rearrangement Overview