Related Experiment Video
Updated: Sep 12, 2025
Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease
Published on: June 16, 2020
Classic lipid profile and lipoprotein(a) in systemic sclerosis: a systematic review and meta-analysis of case-control
Christina Mastori-Kourmpani1, Anastasios Makris2, Evangelos Liberopoulos3
1School of Medicine, European University Cyprus, Diogenis Str 6 Nicosia, Nicosia, 2404, Cyprus.
Background And Aims:
Systemic sclerosis (SSc) is a systemic autoimmune disease characterized by fibrosis, vascular abnormalities, and immune dysfunction. Whether patients with SSc exhibit lipid profile abnormalities, which may increase cardiovascular risk, remains uncertain. Our aim was to systematically investigate whether total cholesterol (TCHOL), triglycerides (TRG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and Lipoprotein (a) [Lp(a)] are affected in SSc patients.
Methods:
PubMed and Cochrane library databases were systematically searched up to 30 November 2024 for studies reporting on lipid profile (TCHOL, TRG, HDL-C, LDL-C) and Lp(a) in patients with SSc. Qualitative and quantitative syntheses of data from published prospective and retrospective studies was performed.
Results:
Literature search identified 27 eligible trials including 2503 participants, of whom 1114 were SSc patients and 1389 were healthy controls (HC). The pooled analysis from 24 studies (1001 SSc patients and 1254 HC) demonstrated that SSc patients had significantly lower HDL-C levels compared with the HC group (MD:- 5.61 mg/dl, 95% CI- 8.22,- 3.00, I2 = 83%). Regarding TRGs, pooled analysis from 24 studies (1016 SSc patients and 1246 HC) showed significantly higher levels in SSc compared with HC (MD: 16.98 mg/dl, 95% CI 8.28, 25.68, I2 = 68%). Similarly, the pooled analysis from 3 studies (131 SSc patients and 206 HC) showed significantly higher Lp(a) levels in SSc compared with HC (MD: 15.66 mg/dl, 95% CI 6.77, 24.55, I2 = 5%). No significant differences were observed in TCHOL (MD: 0.94 mg/dl, 95% CI- 10.23, 12.10, I2 = 93%), and LDL-C (MD:- 6.12 mg/dl, 95% CI- 16.00, 3.77, I2 = 95%) levels between SSc and HC groups.
Conclusions:
HDL-C levels are decreased in SSc, contrary to TRG and Lp(a) levels, which are increased. These findings may have implications in assessing cardiovascular risk in patients with SSc.
Trail Registry:
CRD42024607564.
More Related Videos
07:29Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
Published on: October 12, 2017
09:15Differential Effects of Lipid-lowering Drugs in Modulating Morphology of Cholesterol Particles
Published on: November 10, 2017
Related Concept Videos
01:26Atherosclerosis III: Management
01:30Atherosclerosis I: Introduction
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
01:27Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents