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Updated: Sep 8, 2025

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Racial Differences in Screening Eligibility by Breast Density After State-Level Insurance Expansion.

Mattia A Mahmoud1, Sarah Ehsan1, Sara P Ginzberg2

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|August 5, 2025
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Summary

Pennsylvania’s supplemental breast cancer screening law offers limited eligibility for Black women due to lower breast density and risk estimates. The criteria show poor sensitivity for identifying false-negative mammograms in Black women, highlighting potential disparities in breast cancer screening effectiveness.

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Area of Science:

  • Radiology
  • Oncology
  • Public Health Policy

Background:

  • Dense breast tissue increases the risk of false-negative mammograms.
  • Supplemental screening may benefit women with dense breasts.
  • Pennsylvania mandated insurance coverage for supplemental breast cancer screening.

Purpose of the Study:

  • To assess the outcomes of Pennsylvania's law mandating insurance coverage for supplemental breast cancer screening.
  • To evaluate eligibility and false-negative mammogram rates among Black and White women.

Main Methods:

  • Cross-sectional study of 68,478 women (Black and White, aged 40-74) undergoing mammography.
  • Analysis of eligibility for supplemental screening based on breast density and lifetime cancer risk.
  • Comparison of false-negative mammogram rates between racial groups.

Main Results:

  • Fewer Black women met eligibility criteria for supplemental screening compared to White women.
  • The criteria demonstrated lower sensitivity for detecting false-negative mammograms in Black women.
  • Using breast density alone for supplemental screening recommendations may lead to unnecessary magnetic resonance imaging referrals.

Conclusions:

  • Pennsylvania's supplemental screening criteria have limited ability to identify women at risk for false-negative mammograms, particularly Black women.
  • The criteria may not accurately reflect breast cancer risk in Black women, potentially exacerbating health disparities.
  • Current supplemental screening guidelines may require re-evaluation to ensure equitable access and effectiveness for all women.