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The Association of Long COVID and CKD: Findings from the National Clinical Cohort Collaborative
A Jerrod Anzalone1, Spencer Krichevsky2, Yun Jae Yoo3
1Department of Biostatistics, College of Public Health, University of Nebraska Medical Center, Omaha, Nebraska.
Insights
Chronic kidney disease (CKD) increases the risk of developing Long COVID. Even mild CKD and new kidney problems after COVID-19 are linked to higher Long COVID rates, impacting recovery.
Area of Science:
- Nephrology
- Infectious Diseases
- Public Health
Background:
- The association between chronic kidney disease (CKD) and Long COVID in large patient cohorts remains underreported.
- Understanding this link is crucial for managing post-COVID-19 health outcomes.
Purpose of the Study:
- To investigate the association between baseline CKD and Long COVID risk.
- To examine if incident CKD or kidney function decline after COVID-19 is linked to Long COVID.
Main Methods:
- Utilized data from 59 US healthcare systems (N3C COVID Enclave) for adults with acute COVID-19 (Oct 2021-Sep 2023).
- Employed propensity score matching to analyze baseline CKD/ESKD and Long COVID risk.
- Assessed incident CKD/ESKD and eGFR decline in patients without baseline kidney disease.
Main Results:
- Baseline CKD/ESKD, including mild cases, significantly increased Long COVID risk (sHR 1.13-1.15).
- Among patients without baseline CKD, incident CKD/ESKD (sHR 1.65) and eGFR decline (sHR 1.21) were associated with Long COVID.
Conclusions:
- CKD, even mild, is a significant risk factor for developing Long COVID.
- Long COVID is associated with the development of new kidney disease and declining kidney function post-infection.
Abstract
No abstract available in PubMed .
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