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Updated: Sep 12, 2025

Recapitulation of an Ion Channel IV Curve Using Frequency Components
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Org 34167 rescues voltage dependence of mutant channels and normalizes hyperexcitability in HCN1 epilepsy

Lauren E Bleakley1, Chaseley E McKenzie1, Khaing Phyu Aung1

  • 1The Florey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, Victoria, Australia.

Epilepsia
|August 5, 2025
PubMed
Abstract

Keywords:
HCN1 biophysicsassociated morbiditiesgenetic epilepsyion channelsprecision medicinesmall molecule

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