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Related Concept Videos

Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

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Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
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Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

352
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
352
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

204
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
204
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

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Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
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Cross-reactivity00:42

Cross-reactivity

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Modeling The Lifecycle Of Ebola Virus Under Biosafety Level 2 Conditions With Virus-like Particles Containing Tetracistronic Minigenomes
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Monkeypox Virus Clade IIa Infections, Liberia, 2023-2024.

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    Monkeypox virus genome sequencing in Liberia revealed 5 clade IIa genomes. The study found no sustained human transmission, indicating separate animal-to-human monkeypox virus spillovers.

    Keywords:
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    Area of Science:

    • Virology
    • Genomics
    • Epidemiology

    Background:

    • Monkeypox virus (MPXV) is a zoonotic orthopoxvirus with potential for human transmission.
    • Understanding MPXV transmission dynamics and genetic diversity is crucial for public health surveillance.

    Purpose of the Study:

    • To perform whole-genome sequencing of MPXV from clinical samples in Liberia.
    • To investigate the transmission patterns and genetic lineage of MPXV in the region.

    Main Methods:

    • Whole-genome sequencing of MPXV from clinical samples.
    • Phylogenetic analysis to determine viral lineage and evolutionary relationships.

    Main Results:

    • Successfully sequenced 5 MPXV clade IIa genomes from Liberian samples.
    • Analysis indicated no evidence of sustained human-to-human transmission.
    • Findings suggest multiple independent zoonotic spillover events from a diverse viral reservoir.

    Conclusions:

    • The MPXV strains in Liberia likely originated from independent zoonotic events.
    • Continued genomic surveillance is essential for detecting novel MPXV lineages and understanding transmission.
    • Public health strategies should consider the possibility of ongoing zoonotic introductions.