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Fast Hemostatic, Antimicrobial Multifunctional Gelatin-Based Hydrogel Dressing Loading Bifunctional Cu/ZIF-8 for
Zhichao Zhang1,2, Xijing Zhuang1,2, Xufeng Dong1,3
1Central Hospital of Dalian University of Technology, Dalian, 116089, P. R. China.
ACS Applied Bio Materials
|August 5, 2025
Summary
A new hydrogel wound dressing combines curcumin-loaded nanoparticles with a dual-polymer gel. This advanced dressing shows excellent biocompatibility and potent antimicrobial activity, releasing medication in acidic conditions to fight infection.
Area of Science:
- Biomaterials Science
- Wound Healing
- Nanotechnology
Background:
- Moist wound environments are prone to infection, prolonging inflammation.
- Current wound dressings often lack multifunctionality, struggling with bleeding and bacterial control.
- Developing advanced wound care solutions is crucial.
Purpose of the Study:
- To create a novel, multifunctional hydrogel wound dressing.
- To enhance antimicrobial efficacy and biocompatibility for wound management.
Main Methods:
- Synthesized curcumin (Cur)-loaded bimetallic organic framework (Cu/ZIF-8) nanoparticles.
- Developed a hydrogel carrier using methacryloylated gelatin (GelMA) and methacryloylated hyaluronic acid (HAMA).
- Characterized curcumin loading, pH-responsive release, biocompatibility, hemolytic activity, and antimicrobial efficacy.
Main Results:
- Achieved 45.6% curcumin loading in Cu/ZIF-8@Cur nanoparticles.
- Demonstrated excellent biocompatibility (>80% cell survival) and low hemolytic activity (<5%).
- Exhibited potent antimicrobial activity (≥99%) against E. coli and S. aureus, with pH-responsive release in acidic environments.
Conclusions:
- The developed hydrogel dressing overcomes limitations of traditional gelatin-based dressings, offering improved hemostatic and antimicrobial properties.
- The pH-responsive, antimicrobial hydrogel shows significant potential for clinical wound care applications.
