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Updated: Jul 9, 2026

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Engineered cyclodextrin-protein domain interface modulation and application in nanoscale delivery systems development

Qiyue Wang1, Chenguang Guo1, Yu Ding2

  • 1School of Pharmaceutical Science, Nanjing Tech University, Nanjing 211816, China.

Colloids and Surfaces. B, Biointerfaces
|August 5, 2025
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Summary

Cyclodextrins (CDs) enhance protein drug stability and delivery by forming nanoplatforms. This review explores CD properties, protein interactions, and applications for improved therapeutic efficiency.

Keywords:
CD-derivativesCyclodextrinsDrug deliveryProtein coronaProtein stabilization

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Area of Science:

  • Biomaterials Science
  • Pharmaceutical Sciences
  • Nanotechnology

Background:

  • Proteins are vital therapeutics but suffer from poor stability, rapid metabolism, and inefficient delivery.
  • Biocompatible materials offer a strategy to overcome these limitations and enhance protein drug efficacy.
  • Cyclodextrins (CDs) show promise for protein drug formulation due to their unique structure and properties.

Purpose of the Study:

  • To review the physicochemical properties of Cyclodextrins (CDs) and their derivatives.
  • To summarize the interactions between proteins and CD-based nanoplatforms.
  • To explore the applications of CDs in improving protein drug stability, delivery, and biological signaling.

Main Methods:

  • Literature review of physicochemical properties of CDs and their derivatives.
  • Analysis of protein-CD interactions, including stability, corona formation, and drug delivery mechanisms.
  • Discussion of CD applications in protein therapeutics and biological pathways.

Main Results:

  • CDs can positively modulate protein drug stability and solubility.
  • CD-based nanoplatforms facilitate effective protein drug delivery and cellular uptake.
  • CDs demonstrate potential for direct involvement in biological signaling pathway regulation.

Conclusions:

  • Cyclodextrins offer a versatile platform for overcoming challenges in protein-based drug development.
  • Sophisticated design of CD-related systems can significantly enhance therapeutic outcomes.
  • Further research into CD-protein interactions will drive innovation in protein drug delivery.