Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tooth Anatomy01:21

Tooth Anatomy

1.0K
The human tooth enables us to eat a variety of foods, speak clearly, and even aid in shaping our faces. Teeth are composed of various elements that work together. Here's a detailed look at the anatomy of a human tooth.
The Crown, Neck, and Root
The visible part of the tooth is referred to as the crown. It's covered by enamel, the hardest substance in the human body. The crown is uniquely shaped for each type of tooth, allowing for different functions such as cutting, tearing, or...
1.0K
Teeth01:15

Teeth

692
The formation of teeth, also known as odontogenesis, is a complex process that begins in utero, around the sixth week of embryonic development. There are three stages to this process: the bud stage, the cap stage, and the bell stage.
In the bud stage, the tooth germ (an aggregation of cells) starts to form in the developing jawbone. During the cap stage, the tooth germ differentiates into enamel organ, dental papilla, and dental sac, which will later develop into the tooth's enamel, dentin...
692

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Elucidating the formation of 3D interconnected honeycomb-like hollow porous biochar with corrugated internal pore walls from lignin-rich secondary waste biomass.

International journal of biological macromolecules·2026
Same author

Linker-Enabled Self-Nitridation and Multistep Pyrolysis Pathways of Cu-Triazolate MOFs Toward Cu<sub>3</sub>N/Carbon Fibers.

Angewandte Chemie (International ed. in English)·2026
Same author

Transcatheter Patent Foramen Ovale Closure and Complete Remission of Migraine in Children: A Single-Center Retrospective Cohort Study.

Pediatric cardiology·2026
Same author

Root-oriented replantation with socket reconstruction as a regenerative strategy for periodontally hopeless teeth: a pilot feasibility report.

BMC oral health·2026
Same author

Functional Indium Vacancies in Indium Phosphors Chalcogenides.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

From synapse to strategy: a bibliometric map of ionotropic glutamate receptors in depression.

Naunyn-Schmiedeberg's archives of pharmacology·2026
Same journal

Co-assistant networks by pathology foundation model and convolutional neural network for gigapixel whole slide image analysis.

Medical image analysis·2026
Same journal

MBAS2024: A large-scale benchmark for multi-class bi-atrial segmentation in multi-center contrast-enhanced MRIs.

Medical image analysis·2026
Same journal

Respiratory motion augmentation for personalized super-resolution (RMApSR) of 3D cine MR images in MRI-guided radiotherapy.

Medical image analysis·2026
Same journal

Biom3d, a modular framework to host and develop 3D segmentation methods.

Medical image analysis·2026
Same journal

Embracing intra-class heterogeneity for semi-supervised medical image segmentation: From diversity to precision.

Medical image analysis·2026
Same journal

Real-time patient-specific microwave ablation zone prediction via a unified bioheat solver and MRI-informed perturbation learning.

Medical image analysis·2026
See all related articles

Related Experiment Video

Updated: Sep 12, 2025

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment
07:32

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Published on: February 23, 2024

1.3K

CLIK-Diffusion: Clinical Knowledge-informed Diffusion Model for Tooth Alignment.

Yulong Dou1, Han Wu1, Changjian Li2

  • 1School of Biomedical Engineering & State Key Laboratory of Advanced Medical Materials and Devices, ShanghaiTech University, Shanghai 201210, China.

Medical Image Analysis
|August 5, 2025
PubMed
Summary
This summary is machine-generated.

CLIK-Diffusion, a novel clinical knowledge-informed diffusion model, automates tooth alignment by transforming landmark coordinates, improving orthodontic treatment efficiency and accuracy for misaligned teeth.

Keywords:
3D tooth modelClinical knowledge constraintDiffusion modelOrthodonticsTooth alignment

More Related Videos

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

13.5K
Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures
09:10

Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures

Published on: August 5, 2021

1.9K

Related Experiment Videos

Last Updated: Sep 12, 2025

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment
07:32

Author Spotlight: 3D Movement Assessment of Maxillary Posterior Teeth in Clear Aligner Treatment

Published on: February 23, 2024

1.3K
Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision
07:57

Accuracy in Dental Medicine, A New Way to Measure Trueness and Precision

Published on: April 29, 2014

13.5K
Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures
09:10

Digital Hybrid Model Preparation for Virtual Planning of Reconstructive Dentoalveolar Surgical Procedures

Published on: August 5, 2021

1.9K

Area of Science:

  • Biomedical Engineering
  • Artificial Intelligence in Dentistry
  • Orthodontics

Background:

  • Traditional semi-automatic tooth alignment is labor-intensive and relies heavily on dentist expertise, leading to prolonged treatment.
  • Existing automatic methods often oversimplify tooth alignment by directly estimating rigid transformations, neglecting crucial clinical insights and rules for effective orthodontic treatment.

Purpose of the Study:

  • To introduce CLIK-Diffusion, a Clinical Knowledge-informed Diffusion model designed for automatic tooth alignment.
  • To address the limitations of current methods by incorporating clinical knowledge and formulating tooth alignment as a landmark transformation problem.

Main Methods:

  • CLIK-Diffusion formulates tooth alignment as a landmark coordinate generation task, learning the distribution of normal occlusion.
  • Hierarchical constraints are implemented at dental-arch, inter-tooth, and individual-tooth levels to ensure clinically valid alignment.
  • The model predicts post-orthodontic landmarks and estimates rigid transformations for each tooth based on pre- and post-orthodontic landmark coordinates.

Main Results:

  • CLIK-Diffusion demonstrates exceptional performance and strong applicability in real-world malocclusion cases.
  • The model's approach effectively integrates essential clinical knowledge for accurate tooth alignment.
  • Comparative evaluations show superior results compared to state-of-the-art methods in orthodontic treatment.

Conclusions:

  • CLIK-Diffusion offers a significant advancement in automatic tooth alignment by integrating clinical knowledge into a diffusion model framework.
  • The proposed method enhances the efficiency and accuracy of orthodontic treatments, particularly for complex malocclusions.
  • The developed dataset and code are publicly available, facilitating further research and development in AI-driven orthodontics.