Chronic administration of D-amphetamine increases [3H]spiroperidol binding in cat brain

Administration of D-amphetamine sulfate twice daily for 10 consecutive days, in doses increasing from 10 mg/kg per day (i.p.) to 30 mg/kg per day resulted in significant increases in the Bmax for [3H]spiroperidol receptor binding in the striatum (+44.7%) and limbic forebrain (+40.3%) in cats. There were no significant changes in the KD value for either brain region. A single dose of amphetamine (15 mg/kg i.p.) produced no significant changes in [3H]spiroperidol binding in either brain region. These data are in contrast with previous studies which reported a significant decrease in dopamine receptor binding following chronic amphetamine treatment in rats.