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Updated: Sep 12, 2025
05:31
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
Published on: January 26, 2024
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Immunological dysregulation in preeclampsia: Pathogenesis and clinical implications
1Department of Obstetrics and Gynecology, Beijing Friendship Hospital, Capital Medical University, 100050 Beijing, China.
International Immunopharmacology
|August 5, 2025
Summary
Hypertensive disorders of pregnancy stem from immune imbalance at the maternal-fetal interface. Immune-targeted therapies offer promising avenues for improving outcomes in preeclampsia and related conditions.
Area of Science:
- Reproductive Immunology
- Maternal-Fetal Medicine
- Immunopathology
Background:
- Hypertensive disorders of pregnancy (HDP) are major causes of maternal and fetal mortality.
- HDP pathogenesis involves immune dysregulation at the maternal-fetal interface, leading to placental dysfunction.
Purpose of the Study:
- To review the role of immune microenvironment imbalance in HDP pathogenesis.
- To highlight the potential of immune-targeted therapies for HDP management.
Main Methods:
- Review of current literature on HDP immunology and therapeutics.
- Analysis of immune cell dysregulation, genetic/epigenetic factors, and emerging treatments.
Main Results:
- Immune imbalance, including aberrant immune cell interactions and genetic factors, drives HDP.
- Trophoblast dysfunction, placental ischemia, and systemic inflammation are key pathological features.
Conclusions:
- Immune microenvironment imbalance is critical in HDP.
- Immunologically based therapies show promise for early prediction and personalized intervention in HDP.
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