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Updated: Sep 12, 2025

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Synthetic strategies and therapeutic applications of sulfur-containing molecules
Nur Farisya Shamsudin1, Kamal Rullah1
1Drug Discovery and Synthetic Chemistry Research Group, Department of Pharmaceutical Chemistry, Kulliyyah of Pharmacy, International Islamic University Malaysia, Bandar Indera Mahkota, 25200 Kuantan, Pahang, Malaysia.
Abstract:
Sulfur-containing molecules play a crucial role in medicinal chemistry, with over 300 FDA-approved sulfur-based drugs exhibiting diverse biological activities and therapeutic potentials. Notably, recent trends show a steady rise in their prevalence, with sulfur incorporated into approximately 10-20 % of newly FDA-approved drugs from 2020 to 2024, rising from 11 % in 2020 to 20 % in 2024. The unique chemical properties of sulfur, including its ability to exist in multiple oxidation states, engage in varied bonding interactions, and enhance molecular stability and solubility, contribute to improved pharmacokinetic and pharmacodynamic profiles. This review highlights synthetic approaches for incorporating sulfur, including sulfonamides, sulfones, and thioethers, and explores their therapeutic applications across antibacterial, antidiabetic, anticancer, and anti-inflammatory drugs. In conclusion, sulfur-based compounds remain essential for drug development, driving innovation and offering broad-spectrum therapeutic solutions.
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