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Updated: Sep 12, 2025

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A cholesterol-dependent switch controls organ-specific metastasis in pancreatic cancer
Julie Haenlin1, Almut Schulze2
1Division of Tumor Metabolism and Microenvironment, German Cancer Research Center, Heidelberg, Germany; Faculty of Biosciences, Heidelberg University, Heidelberg, Germany.
Developmental Cell
|August 5, 2025
Abstract:
As different organs offer distinct chemical microenvironments, cancer cells require unique metabolic adaptation to colonize distant sites. In a recent issue of Nature, Rademaker et al. identify PCSK9 as a predictive factor for metastatic colonization of different organs, showing adaptation of cancer cells to different environments by regulating cholesterol metabolism.

