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Updated: Sep 12, 2025

High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation
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High-Resolution Endocardial and Epicardial Optical Mapping in a Sheep Model of Stretch-Induced Atrial Fibrillation

Published on: July 29, 2011

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[Atrial fibrillation in ion channel diseases and cardiomyopathies]

Fabienne Kreimer, Michael Gotzmann, Lars Eckardt

    Deutsche Medizinische Wochenschrift (1946)
    |August 5, 2025
    PubMed

    Insights

    Atrial fibrillation (AF) management in cardiomyopathies requires a comprehensive approach. The AF-CARE strategy, emphasizing rhythm control and stroke prevention, improves outcomes for these high-risk patients.

    Area of Science:

    • Cardiology
    • Electrophysiology
    • Internal Medicine

    Background:

    • Atrial fibrillation (AF) is highly prevalent in cardiomyopathies and cardiac channelopathies.
    • This association significantly elevates risks of thromboembolic events and heart failure.
    • Current management strategies require optimization for these complex patient groups.

    Purpose of the Study:

    • To review the management of atrial fibrillation in patients with cardiomyopathies and cardiac channelopathies.
    • To highlight the integration of the "AF-CARE" concept from the 2024 ESC guidelines.
    • To emphasize a comprehensive, individualized approach to AF care in these populations.

    Main Methods:

    • Literature review focusing on recent evidence and clinical guidelines.
    • Analysis of the "AF-CARE" framework: rhythm/rate control, stroke prevention, comorbidity management.
    • Discussion of anticoagulation strategies tailored to specific cardiomyopathies and risk scores (CHA2DS2-VA).

    Main Results:

    • Rhythm control is increasingly favored over rate control for superior clinical outcomes in AF.
    • Anticoagulation decisions necessitate careful consideration of cardiomyopathy type and CHA2DS2-VA score.
    • The AF-CARE approach promotes integrated management for improved patient prognosis.

    Conclusions:

    • Integrated management using the AF-CARE concept is crucial for optimizing AF treatment in cardiomyopathies.
    • Rhythm control and individualized anticoagulation strategies are key components for better outcomes.
    • Continuous monitoring and personalized care enhance long-term quality of life for affected patients.

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