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Updated: May 1, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Diffuse large B-cell lymphoma masquerading as demyelination.

Christopher Paisey¹, Christy Kaiyamo², Chun Lap Pang³

¹Southmead Hospital, Bristol, UK christopher.paisey@nbt.nhs.uk.

Practical Neurology

|August 5, 2025

Summary

This summary is machine-generated.

Diffuse large B cell lymphoma (DLBCL) can present with neurological symptoms, posing a diagnostic challenge. Early suspicion and tissue biopsy are crucial for diagnosing CNS lymphoma, even with imaging mimicking demyelination.

Keywords:

HAEMATOLOGY HISTOPATHOLOGY LYMPHOMA NEURORADIOLOGY

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Area of Science:

Neurology
Oncology
Pathology

Background:

Diffuse large B cell lymphoma (DLBCL) can present with neurological symptoms, creating diagnostic challenges.
Central nervous system (CNS) lymphoma is rare, and imaging findings may mimic demyelinating diseases.
Prompt diagnosis is essential for effective treatment and improved patient outcomes.

Purpose of the Study:

To highlight the diagnostic challenges of DLBCL presenting with neurological symptoms.
To present a case study of a patient with DLBCL initially manifesting with neurological signs.
To emphasize the importance of tissue diagnosis in suspected CNS lymphoma.

Main Methods:

Case report detailing clinical course and neurological presentation.
Review of imaging findings, including MRI.
Postmortem pathological examination with immunohistochemistry for diagnosis confirmation.

Main Results:

The patient presented with predominantly neurological symptoms, delaying DLBCL diagnosis.
MRI revealed CNS lesions consistent with demyelination, a common misdiagnosis.
Postmortem examination confirmed CNS lymphoma through immunohistochemistry of brain and spinal lesions.

Conclusions:

Neurological presentation of DLBCL poses a significant diagnostic challenge.
High clinical suspicion is paramount, even when imaging suggests other conditions like demyelination.
Tissue biopsy (skin, lymph node, or brain) is essential for definitive diagnosis of suspected CNS lymphoma.