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Multimodal PAI/OCT Imaging System for Precision Diagnosis and Therapy in Atopic Dermatitis: A Pilot Study
Jiayi Yang1,2, Qi Chen1, Chunxiao Li1
1Institute of Photomedicine, Shanghai Dermatology Hospital, School of Medicine, Tongji University, Shanghai, China.
Journal of Biophotonics
|August 5, 2025
Summary
This study introduces a novel photoacoustic imaging/optical coherence tomography system for precise, noninvasive atopic dermatitis (AD) diagnosis. The system quantifies disease progression and treatment response, aiding tailored therapeutic strategies.
Area of Science:
- Biomedical Imaging
- Dermatology
- Translational Medicine
Background:
- Atopic dermatitis (AD) diagnosis relies on subjective assessments, limiting objective evaluation.
- Current methods lack quantitative biomarkers for disease progression and therapeutic response.
- Noninvasive imaging techniques are needed for precise AD assessment.
Purpose of the Study:
- To develop and validate an integrated photoacoustic imaging (PAI) and optical coherence tomography (OCT) system for quantitative AD evaluation.
- To assess the efficacy of Crisaborole in an MC903-induced mouse model of AD-like dermatitis.
- To establish in vivo dynamic monitoring of AD pathophysiology and treatment response.
Main Methods:
- An integrated PAI/OCT system was utilized for noninvasive imaging of MC903-induced AD-like dermatitis in mice.
- Quantitative analysis of vascularization and epidermal changes was performed using PAI/OCT data.
- Crisaborole treatment efficacy was evaluated through multimodal imaging and validated by histopathology.
- In vivo imaging captured dynamic alterations during AD progression and treatment.
Main Results:
- Multimodal imaging revealed Crisaborole significantly suppressed pathological angiogenesis and tissue remodeling in AD models.
- Quantified reductions in vascular junctions, density, and vessel length were observed with Crisaborole treatment.
- Significant epidermal thinning and signal changes were documented, correlating with treatment efficacy.
- The PAI/OCT system successfully captured dynamic vascular restructuring and epidermal alterations in vivo.
Conclusions:
- The integrated PAI/OCT system offers complementary functional and structural biomarkers for precise AD diagnosis.
- This multimodal approach enables real-time monitoring of AD pathophysiology and therapeutic responses.
- The quantitative multiparametric characterization supports clinical translation and personalized therapeutic strategies for AD.
