From reference to reality: identifying noncanonical peptides
Ellen Frances Shute1, Pavel Sinitcyn1
1AI Technology for Life, Department of Information and Computing Sciences, Utrecht University, Utrecht 3584 CC, The Netherlands; Biomolecular Mass Spectrometry and Proteomics, Department of Pharmaceutical Sciences, Utrecht University, Utrecht 3584 CH, The Netherlands.
Trends in Genetics : TIG
|August 5, 2025
Abstract:
The translation of genome sequence variation into proteoform diversity lies at the heart of the central dogma. In a recent study, Zhu et al. developed a graph-based algorithm that models gene expression complexity, providing an exhaustive answer to the question: 'Given a set of genomic variants, which proteins might one see?'


