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Quantitative analysis of iris surface smoothness in normal population
Hanieh Fakhredin1, Tahereh Mahmoudi2, Soha Nohasfarmaniyeh2
1Ophthalmology Department, Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Scientific Reports
|August 5, 2025
Summary
This study establishes normative iris Smoothness Index (SI) data using AS-OCT in healthy adults. The findings provide a baseline for iris surface analysis and future research on ocular conditions.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Medical Imaging
Background:
- The iris surface topography is crucial for understanding ocular health.
- Normative data for iris surface parameters like the Smoothness Index (SI) are lacking.
- Anterior Segment Optical Coherence Tomography (AS-OCT) offers high-resolution imaging of ocular structures.
Purpose of the Study:
- To establish normative data for the iris Smoothness Index (SI) in a healthy adult population.
- To investigate the influence of age, sex, and pupil dilation on iris SI.
- To provide a reference range for iris SI for future clinical and research applications.
Main Methods:
- Anterior Segment Optical Coherence Tomography (AS-OCT) was used to image the iris surface.
- The Smoothness Index (SI) was calculated for multiple meridians in 198 eyes from 99 healthy participants.
- Data were analyzed for associations with age, sex, and pupil dilation status.
Main Results:
- The average iris Smoothness Index (SI) was 0.812 ± 0.036.
- SI showed a slight increase with age and was higher in undilated pupils.
- No significant differences in SI were observed between sexes or between the two eyes.
Conclusions:
- Normative data for iris SI were established in a healthy Iranian population using AS-OCT.
- Iris SI is influenced by age and pupil dilation, but not significantly by sex.
- These findings serve as a reference for evaluating iris surface characteristics in health and disease.
