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Determination of Aggregate Surface Morphology at the Interfacial Transition Zone ITZ
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Quantitative analysis of iris surface smoothness in normal population.

Hanieh Fakhredin1, Tahereh Mahmoudi2, Soha Nohasfarmaniyeh2

  • 1Ophthalmology Department, Retina Service, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Scientific Reports
|August 5, 2025
PubMed
Summary

This study establishes normative iris Smoothness Index (SI) data using AS-OCT in healthy adults. The findings provide a baseline for iris surface analysis and future research on ocular conditions.

Keywords:
AS-OCTAnterior segment OCTNormal populationNormative dataSISmoothness index

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Area of Science:

  • Ophthalmology
  • Biomedical Engineering
  • Medical Imaging

Background:

  • The iris surface topography is crucial for understanding ocular health.
  • Normative data for iris surface parameters like the Smoothness Index (SI) are lacking.
  • Anterior Segment Optical Coherence Tomography (AS-OCT) offers high-resolution imaging of ocular structures.

Purpose of the Study:

  • To establish normative data for the iris Smoothness Index (SI) in a healthy adult population.
  • To investigate the influence of age, sex, and pupil dilation on iris SI.
  • To provide a reference range for iris SI for future clinical and research applications.

Main Methods:

  • Anterior Segment Optical Coherence Tomography (AS-OCT) was used to image the iris surface.
  • The Smoothness Index (SI) was calculated for multiple meridians in 198 eyes from 99 healthy participants.
  • Data were analyzed for associations with age, sex, and pupil dilation status.

Main Results:

  • The average iris Smoothness Index (SI) was 0.812 ± 0.036.
  • SI showed a slight increase with age and was higher in undilated pupils.
  • No significant differences in SI were observed between sexes or between the two eyes.

Conclusions:

  • Normative data for iris SI were established in a healthy Iranian population using AS-OCT.
  • Iris SI is influenced by age and pupil dilation, but not significantly by sex.
  • These findings serve as a reference for evaluating iris surface characteristics in health and disease.