Related Experiment Video
Updated: Sep 12, 2025
07:25
Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
Published on: December 17, 2019
8.2K
Macrophage bibliometric study and visualization in myocardial ischemia-reperfusion
Zhenhao Li1, Baocheng Pei1, Jun Ma1
1Department of Cardiac Surgery, Weifang People's Hospital, Shandong Second Medical University, 151 Guangwen Street, Kuiwen District, Weifang, Shandong, 261000, China.
Journal of Cardiothoracic Surgery
|August 5, 2025
Summary
This bibliometric analysis reveals macrophages are central to myocardial ischemia-reperfusion injury research. Future studies should focus on molecular targets and inhibition strategies for this condition.
Area of Science:
- Cardiology
- Immunology
- Biomedical Research
Background:
- Myocardial ischemia-reperfusion injury (IRI) exacerbates damage after blood flow restoration, a significant cause of post-surgical mortality.
- Research indicates strong correlations between myocardial IRI and factors like autophagy, macrophages, and endoplasmic reticulum stress.
Purpose of the Study:
- To systematically review and analyze research on macrophages in myocardial IRI using bibliometric methods.
- To identify current research hotspots and forecast future directions in the field of myocardial IRI and macrophage involvement.
Main Methods:
- A comprehensive literature search was performed on the Web of Science Core Collection (2008-2024) for myocardial IRI and macrophages.
- Bibliometric tools (CiteSpace, VOSviewer, Excel) were employed for analyzing publication trends, countries, institutions, journals, authors, and keywords.
- Visual maps were generated to illustrate research landscapes and predict future trends.
Main Results:
- A total of 1039 studies were analyzed, showing a dynamic increase in publications.
- China and the United States lead in publications, with Fudan University and the Chinese Academy of Medical Sciences as prominent institutions.
- Current research hotspots include inflammatory processes, mitochondrial autophagy, endoplasmic reticulum stress, and macrophage roles in myocardial IRI.
Conclusions:
- Macrophages are a critical focus in recent myocardial IRI research.
- This bibliometric study offers a comprehensive overview of the research landscape, guiding future investigations.
- Future research may concentrate on molecular proteins and effective strategies to mitigate myocardial IRI.
