A novel approach to smart-assisted schizophrenia screening based on Raman spectroscopy and deep learning

In this study, serum Raman spectra are introduced into the screening of schizophrenia. We collect serum Raman spectra from schizophrenic and healthy individuals, classified them based on four convolutional neural networks, and developed an assisted screening method for schizophrenia based on serum Raman spectra. We also introduce Markov transition field (MTF), which is commonly used in time-series signal processing, into Raman spectral analysis, and convert 1D Raman spectral sequences into 2D spectrograms to enrich the method of Raman spectral analysis. The experimental results show that the performance of the model trained based on MTF is overall better than that of the model trained based on 1D spectral sequences.