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Related Experiment Video

Updated: Jun 28, 2026

Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging

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Published on: February 7, 2014

Midlife aging and performance study (MAPS): evaluating biological aging through a physical capacity battery.

Roy Tzemah-Shahar¹, Ilona Shapiro², Einat Kodesh³

¹School of Nursing, Faculty of Health and Social Welfare, University of Haifa, Haifa, Israel.

|August 6, 2025

Summary

Physical capacity (PC) assessment in midlife correlates with biological age (BA). Better PC indicates younger BA, suggesting PC can track aging and guide health interventions effectively.

Keywords:

Accelerated aging Biological age Exercise Physical fitness

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Area of Science:

Gerontology
Biomedical science
Public health

Background:

Aging is a significant risk factor for chronic diseases, but its heterogeneity presents challenges for intervention.
Current methods for estimating biological age (BA) using laboratory markers may not directly translate to actionable behavioral goals for healthier aging.
The Midlife Aging and Performance Study (MAPS) aimed to bridge this gap by exploring physical capacity (PC) as a behavioral marker.

Purpose of the Study:

To investigate the association between a comprehensive physical capacity (PC) assessment and biological age (BA) in midlife adults.
To determine if PC can serve as a functional behavioral marker for assessing aging status.
To evaluate the utility of PC assessment for informing intervention goals and tracking health changes.

Main Methods:

Recruited 112 individuals aged 42-46.
Estimated biological age (BA) using the Klemera-Doubal method from 11 laboratory biomarkers.
Assessed physical capacity (PC) through a battery measuring muscle strength, endurance, balance, agility, and flexibility.

Main Results:

Better performance in strength, endurance, balance, and flexibility domains was significantly correlated with younger biological age (BA) (r = 0.33–0.49, p < 0.001).
A lower composite PC score was associated with an accelerated aging state (BA > chronological age).
Each incremental increase in composite PC score reduced the odds of accelerated aging by 60% (OR = 0.40, 95% CI 0.25–0.64).

Conclusions:

Physical capacity (PC) serves as a valid behavioral marker for assessing biological aging in midlife.
A comprehensive PC assessment battery can identify individuals in an accelerated aging state.
PC assessment offers a functional, accessible tool for population-wide risk screening, intervention guidance, and monitoring health changes over time, independent of laboratory tests.