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The relationship between circadian syndrome and its components with Helicobacter pylori infection risk: a
Haiyan Yang1, Liuying He1, Xiao Zhao1
1Department of Gastroenterology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
Insights
Circadian syndrome (CircS) is an independent risk factor for Helicobacter pylori (H. pylori) infection. Smoking modifies this relationship, and components like central obesity and high blood pressure are linked to increased H. pylori risk.
Area of Science:
- Metabolic health research
- Infectious disease epidemiology
- Gut microbiome studies
Background:
- Circadian syndrome (CircS) offers a more holistic view of metabolic health than metabolic syndrome (MetS).
- Limited research exists on the association between CircS and Helicobacter pylori (H. pylori) infection.
- This study investigates the link between CircS, its components, and H. pylori infection in individuals undergoing health screenings.
Purpose of the Study:
- To determine if CircS is associated with H. pylori infection.
- To identify specific CircS components linked to H. pylori infection.
- To explore the modifying effect of smoking on the CircS-H. pylori relationship.
Main Methods:
- Cross-sectional study of 29,621 individuals undergoing health examinations in Northwest China (July 2021-June 2023).
- H. pylori infection status determined by ¹³C-urea breath test (¹³C-UBT).
- Binary logistic regression analysis used to assess the association between H. pylori infection and CircS and its components, adjusting for covariates.
Main Results:
- H. pylori infection was significantly associated with a higher prevalence of CircS (OR 1.17, P < 0.001), with smoking as a modifier.
- Central obesity, low HDL-C, elevated blood pressure, and short sleep were significantly associated with increased H. pylori infection risk.
- No significant association was found between H. pylori infection and depression, elevated FBG, or elevated TG.
Conclusions:
- Circadian syndrome (CircS) is identified as an independent risk factor for H. pylori infection.
- Smoking status significantly modifies the association between CircS and H. pylori infection.
- Specific CircS components, including central obesity and hypertension, are positively associated with H. pylori infection.
Background:
Circadian syndrome (CircS) provides a more comprehensive reflection of metabolic health than metabolic syndrome (MetS), yet studies exploring its association with H.pylori infection are still limited. The study aimed to examine the association between CircS and its components, as well as H.pylori infection, among individuals undergoing routine health screenings.
Methods:
We collected data from health examination population who underwent a ¹³C-urea breath test (¹³C-UBT) at a tertiary hospital in Northwest China from July 1, 2021, to June 30, 2023, for a cross-sectional study. The study population was divided into H. pylori-positive and H. pylori-negative groups based on H.pylori infection status, and a binary logistic regression model was constructed to analyze the relationship between H.pylori infection and CircS and its components.
Results:
The study included 29,621 individuals, after adjusting for covariates, H.pylori infection showed a significant association with the prevalence of CircS (OR 1.17, 95% CI 1.08,1.27, P < 0.001), with the association being modified by smoking. Additionally, some of the components of CircS were associated with an increased risk of H.pylori infection, including central obesity, lowered high-density lipoprotein-cholesterol (HDL-C), elevated blood pressure (BP), and short sleep (OR 1.12, 95% CI 1.06,1.19; OR 1.14,95% CI 1.08,1.20; OR 1.10,95% CI 1.04,1.17; OR 1.11, 95% CI 1.02,1.20). No significant association was found between depression, elevated fasting blood glucose (FBG) and elevated triglycerides (TG) and H.pylori infection.
Conclusions:
This study identifies CircS as an independent risk factor for H.pylori infection, that smoking appears to modify this relationship, and that some of the CircS components are significantly and positively associated with H.pylori infection.
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