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Advancements in Enteric-coated Microspheres Formulation Development and Mangiferin Drug Delivery for the Treatment of

Swati Yadav1,2, Ranjit K Harwansh1, Rupa Mazumder2

  • 1Institute of Pharmaceutical Research, GLA University, Mathura-281406, India.

Recent Advances in Drug Delivery and Formulation
|August 6, 2025
PubMed
Abstract

Insights

Mangiferin-loaded microspheres show promise in treating ulcerative colitis (UC) by reducing inflammation and colon damage. This novel formulation offers delayed release, enhancing its protective effects against colon ulcers in rats.

Area of Science:

  • Pharmacology
  • Gastroenterology
  • Drug Delivery Systems

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by frequent recurrence.
  • Novel therapeutic strategies are essential for managing UC effectively.
  • This study investigates mangiferin-loaded microspheres as a potential treatment for UC.

Purpose of the Study:

  • To evaluate the protective effects of mangiferin-loaded microspheres in an acetic acid-induced ulcerative colitis model in rats.
  • To assess the anti-inflammatory and antioxidant properties of the microsphere formulation.
  • To compare the efficacy of enteric-coated microspheres with plain mangiferin.

Main Methods:

  • Ulcerative colitis was induced in rats using a 4% acetic acid solution.
  • Mangiferin-loaded microspheres were administered to the experimental group.
  • Macroscopic and microscopic evaluations of colon tissues were performed.
  • Levels of oxidative stress markers, including catalase and glutathione (GSH), were measured.

Main Results:

  • Mangiferin-loaded microspheres significantly reduced inflammatory markers, ulcer activity, and oxidative stress in acetic acid-induced colitis.
  • Improvements were observed in weight loss, macroscopic scores, ulcer area, and histological damage.
  • The microsphere formulation demonstrated delayed-release properties.

Conclusions:

  • Enteric-coated mangiferin microspheres exhibit significant protective effects against colon ulcers in rats.
  • The anti-inflammatory and antioxidant actions of mangiferin contribute to its therapeutic efficacy in UC.
  • This formulation presents a promising approach for managing ulcerative colitis with enhanced drug delivery.
Keywords:
GSHMangiferinacetic acid.catalasecoloninflammationulcer

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