Related Experiment Video
Updated: Sep 12, 2025

Technical Refinement of a Bilateral Renal Ischemia-Reperfusion Mouse Model for Acute Kidney Injury Research
Published on: November 3, 2023
Mortality prediction in geriatric patients with multiple trauma presenting by ambulance
Aynur Yurtseven1, Afşin Emre Kayıpmaz1
1Department of Emergency Medicine, Etlik State Hospital Faculty of Health Sciences, Ankara-Türkiye.
Background:
The Modified 5-Factor Frailty Index (mFI-5) has been shown to predict complications following treatment in geriatric patients. However, few studies have compared the mFI-5 with other trauma scoring systems in cases involving multiple injuries. This study aimed to evaluate the Relationship Between mFI-5, Injury Severity Score (ISS), and Geriatric Trauma Outcome Score (GTOS) and their association with mortality in geriatric trauma patients.
Methods:
This retrospective cohort study included patients aged 65 and older who were admitted to the emergency trauma unit of a tertiary care hospital. Data collected included laboratory parameters, imaging results, blood transfusion requirements, hospitalization status, intensive care unit admission, surgical intervention, ISS, GTOS, mFI-5 scores, and mortality outcomes.
Results:
A total of 241 patients were included, with a mean age of 78.12 (±8.34) years. Falls were the most common cause of trauma (n=142, 58.9%). Thoracic injuries were the most frequently observed (n=86, 53.7%). Patients who died within the first 24 hours of admission had significantly higher ISS (14.1 vs. 26.33), GTOS (119.02 vs. 157.33), and mFI-5 (2.53 vs. 3.33) scores (p=0.001, p=0.001, and p=0.017, respectively). Similar trends were noted for one-month and three-month mortality (p=0.001 for all).
Conclusion:
Scoring systems are essential for early mortality prediction in geriatric trauma patients. ISS, GTOS, and mFI-5 scores have shown similar effectiveness in predicting comorbidities, intensive care unit admission, and mortality in geriatric trauma patients. ISS involves a complex calculation, while GTOS, although specifically designed for geriatric patients, requires additional computations based on the ISS. In contrast, mFI-5 may be more practical in emergency settings because it is easy to calculate.
Insights
The Modified 5-Factor Frailty Index (mFI-5) effectively predicts mortality in geriatric trauma patients, similar to ISS and GTOS. Its ease of calculation makes mFI-5 a practical tool for emergency settings.
Area of Science:
- Geriatric Trauma Research
- Trauma Scoring Systems
- Predictive Analytics in Medicine
Background:
- The Modified 5-Factor Frailty Index (mFI-5) is recognized for predicting complications in geriatric patients.
- Limited research compares mFI-5 with established trauma scores for multi-injury cases.
- This study investigates the relationship between mFI-5, Injury Severity Score (ISS), and Geriatric Trauma Outcome Score (GTOS) in geriatric trauma mortality.
Purpose of the Study:
- To evaluate the association between mFI-5, ISS, and GTOS with mortality in geriatric trauma patients.
- To compare the predictive capabilities of these scoring systems for adverse outcomes.
- To determine the practicality of mFI-5 in emergency trauma care.
Main Methods:
- Retrospective cohort study of geriatric trauma patients (≥65 years).
- Data collection included demographics, injury details, laboratory results, and outcomes (mortality, ICU admission).
- Analysis of ISS, GTOS, and mFI-5 scores in relation to mortality.
Main Results:
- 241 patients (mean age 78.12 years) were analyzed; falls were the most common cause.
- Higher ISS, GTOS, and mFI-5 scores were significantly associated with increased 24-hour, one-month, and three-month mortality (p<0.05).
- All three scoring systems demonstrated similar effectiveness in predicting mortality.
Conclusions:
- Scoring systems are crucial for early mortality prediction in geriatric trauma.
- ISS, GTOS, and mFI-5 show comparable effectiveness in predicting comorbidities, ICU admission, and mortality.
- mFI-5 offers a practical advantage due to its simple calculation, making it suitable for emergency settings.
Related Concept Videos
Actuarial Approach
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Flail Chest-II
Assessment:
1. Clinical Evaluation:
History:
![Semi-quantitative Assessment Using [18F]FDG Tracer in Patients with Severe Brain Injury](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F58641.jpg&w=3840&q=50)
