Related Experiment Video
Updated: Sep 12, 2025
Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
Published on: December 21, 2014
Elevated MMP-9 Is Associated With Accelerated Lung Function Decline and COPD Development: A Prospective Cohort Study
Xinru Ran1,2, Fan Wu2,3, Zihui Wang2
1Guangzhou Medical University-Guangzhou Institute of Biomedicine and Health (GMU-GIBH) Joint School of Life Sciences, Guangzhou Medical University, Guangzhou, China.
Background And Objective:
The imbalance in proteases/antiproteases caused by inflammation contributes to COPD, and matrix metalloproteinase-9 (MMP-9) may play an important role. Therefore, we aimed to investigate the associations of MMP-9 with respiratory health outcomes.
Methods:
This study was conducted in two parts. Firstly, we performed a prospective cohort study to investigate the association of circulating MMP-9 and respiratory health outcomes. Participants completed a questionnaire, spirometry, and chest CT, and provided blood samples at baseline. Follow-up visits were conducted annually. Study outcomes were the development of spirometry-defined COPD, lung function decline, and exacerbations. Secondly, we performed a two-sample Mendelian randomisation (MR) study to evaluate the causal effect between genetically predicted MMP-9 expression and lung function.
Results:
Overall, 1328 participants were included in the baseline analysis, and 1034 (78%) completed the 2-year follow-up. Higher plasma MMP-9 at baseline was associated with chronic respiratory symptoms, severe emphysema, and air trapping. During the 2-year follow-up, each SD increase in plasma MMP-9 was associated with accelerated decline in pre-bronchodilator FEV1 (adjusted difference = 6.4 [95% CI: 0.7-12.1] mL/year) and FVC (adjusted difference = 18.0 [95% CI: 7.6-28.5] mL/year), and a higher exacerbation incidence. In participants with normal spirometry at baseline, higher plasma MMP-9 was associated with progression to spirometry-defined COPD (adjusted OR = 1.93, 95% CI: 1.05-3.57). A MR study demonstrated similar results toward negative associations of genetically predicted MMP-9 expression with FEV1 and FVC.
Conclusion:
The longitudinal cohort and MR study provide evidence that MMP-9 might play a causative role in lung function decline and spirometry-defined COPD development.
More Related Videos
10:21Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
Published on: September 20, 2024
10:37Automated Measurement of Pulmonary Emphysema and Small Airway Remodeling in Cigarette Smoke-exposed Mice
Published on: January 16, 2015
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
01:23Role of Matrix Metalloproteases in Degradation of ECM
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:27Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies
Medical History
01:22Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...