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13:04
Atomic Absorbance Spectroscopy to Measure Intracellular Zinc Pools in Mammalian Cells
Published on: May 16, 2019
Zinc and total parenteral nutrition
Southern Medical Journal
|August 1, 1977
Summary
Zinc supplementation is crucial for patients on prolonged total parenteral nutrition (TPN). Zinc sulfate is recommended, while plasma infusions are ineffective for zinc delivery, with minimal toxicity risk when dosed correctly.
Area of Science:
- Clinical Nutrition
- Trace Element Metabolism
Background:
- Trace element requirements are critical for patient health.
- Total parenteral nutrition (TPN) can lead to deficiencies if not properly supplemented.
- Zinc is an essential trace element with specific nutritional requirements.
Purpose of the Study:
- To evaluate the necessity of zinc supplementation in patients receiving TPN.
- To compare the efficacy of different zinc supplementation methods.
- To assess the safety and potential toxicity of zinc supplementation during TPN.
Main Methods:
- Review of current knowledge on trace element requirements.
- Analysis of the effects of TPN solutions without zinc supplementation.
- Evaluation of zinc sulfate as a preferred supplement.
- Assessment of freeze-dried plasma infusions as a zinc source.
Main Results:
- Zinc supplementation is essential for patients on prolonged TPN.
- Zinc sulfate is an effective and recommended supplement.
- Freeze-dried plasma is an inadequate method for zinc delivery, even short-term.
- Zinc supplementation, following established dosages, presents a low risk of toxicity.
Conclusions:
- Zinc supplementation should be a standard consideration for all patients undergoing extended TPN.
- Zinc sulfate is the supplement of choice for TPN regimens.
- Adequate zinc supply during TPN is achievable with minimal risk of adverse effects.
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