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Investigation of The Hepatoprotective Potential of Liposomal Resveratrol as Polyphenols Against Liver Damage in Streptozotocin Diabetic Rat Model

  • 0Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
International Journal of Medical Sciences +

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August 6, 2025

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August 6, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Liposomal resveratrol (LR) effectively protected against liver damage in diabetic rats by reducing inflammation and oxidative stress. LR demonstrated superior hepatoprotective effects compared to resveratrol alone in this study.

Area Of Science

  • Biochemistry
  • Pharmacology
  • Hepatology

Background

  • Diabetes Mellitus is a global health concern linked to degenerative diseases and significant hepatic injury.
  • Liver dysfunction in diabetes involves cirrhosis, inflammation, apoptosis, and compromised antioxidant defenses.
  • Resveratrol has shown potential, but its efficacy in liposomal form for diabetic liver injury requires investigation.

Purpose Of The Study

  • To evaluate the hepatoprotective effects of Liposomal resveratrol (LR) in streptozotocin (STZ)-induced diabetic rat models.
  • To compare the efficacy of LR at 20 and 40 mg/kg with resveratrol alone (40 mg/kg).
  • To assess the impact on glucose levels, liver enzymes, oxidative stress, inflammation, apoptosis, and liver histology.

Main Methods

  • Diabetes was induced in rats using streptozotocin (STZ).
  • Rats were treated with Liposomal resveratrol (LR) at 20 and 40 mg/kg or resveratrol at 40 mg/kg for five weeks.
  • Key biochemical markers, inflammatory cytokines (TNF-α, IL-6, NF-κB), oxidative stress indices (MDA, catalase, GPx), apoptotic markers (caspase-3, BAX, BCL-2), liver enzymes (SGOT, SGPT, GGT), and liver histology were analyzed.

Main Results

  • LR treatment significantly reversed STZ-induced changes in hepatic function markers, inflammation, and apoptosis.
  • LR administration downregulated inflammatory markers (TNF-α, IL-6, NF-κB), modulated apoptotic proteins (BCL-2, caspase-3, Bax), and improved antioxidant status.
  • LR treatment normalized liver histology, reduced lipid peroxidation, enhanced antioxidant enzyme activity, and proved more effective than resveratrol alone.

Conclusions

  • Liposomal resveratrol (LR) effectively mitigates diabetes-induced oxidative stress and hepatic impairment in rat models.
  • LR demonstrates significant hepatoprotective properties, superior to non-liposomal resveratrol, by modulating inflammatory and apoptotic pathways.
  • LR shows potential as a therapeutic agent for reducing liver dysfunction in diabetic patients.

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