Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.1K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.1K
Cancer Therapies02:49

Cancer Therapies

7.9K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.9K
Nursing Ethical Principles II01:27

Nursing Ethical Principles II

1.3K
Ethical principles are essential in guiding nurses to fulfill their responsibilities, focusing on the quality of nursing care and decision-making. These principles, including autonomy, beneficence, non-maleficence, justice, and fidelity, shape the ethical framework within healthcare settings.
Consider the following scenario, which illustrates how these principles are applied in the care of Mr. John, a fifty-year-old teacher diagnosed with metastatic liver cancer.
Initially, Mr. John's...
1.3K
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

7.8K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.8K
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

175
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
175

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Phase Ib Study to Assess the Safety of Neoadjuvant Trifluridine/Tipiracil With Concurrent Radiation in Resectable Stage II/III Rectal Cancer: The FIERCE Study.

Clinical colorectal cancer·2026
Same author

In Response.

Anesthesia and analgesia·2025
Same author

A Randomized Controlled Trial of Sugammadex versus Neostigmine for Reversal of Rocuronium on Gastric Emptying in Adults Undergoing Elective Colorectal Surgery.

Anesthesia and analgesia·2025
Same author

Liver-First Resection in Patients With Synchronous Colorectal Liver Metastases Is Associated With Inferior Recurrence-Free Survival: Reconsidering the Importance of the Primary Cancer.

Diseases of the colon and rectum·2024
Same author

Organ Preservation and Survival by Clinical Response Grade in Patients With Rectal Cancer Treated With Total Neoadjuvant Therapy: A Secondary Analysis of the OPRA Randomized Clinical Trial.

JAMA network open·2024
Same author

Long-Term Results of Organ Preservation in Patients With Rectal Adenocarcinoma Treated With Total Neoadjuvant Therapy: The Randomized Phase II OPRA Trial.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2023
Same journal

Modern Assessment of Resident and Board-Certified Colorectal Surgeon: Evolution of Competency and Continuing Professional Development.

Clinics in colon and rectal surgery·2026
Same journal

Faculty Development: Cultivating Educators, Advancing Careers, and Lifelong Learning.

Clinics in colon and rectal surgery·2026
Same journal

Constructive Conversations: Mastering the Exchange of Feedback.

Clinics in colon and rectal surgery·2026
Same journal

Surgical Education for the Colorectal Surgeon: Theories, Principles, and Practice.

Clinics in colon and rectal surgery·2026
Same journal

Cultivating Inclusion: The Role of DE&I in Colorectal Surgery Training.

Clinics in colon and rectal surgery·2026
Same journal

International Perspective on Colorectal Surgery Education.

Clinics in colon and rectal surgery·2026
See all related articles

Related Experiment Video

Updated: Sep 12, 2025

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.4K

Personalizing Perioperative Chemotherapy in Colon Cancer.

Joyce H Pang1, Charles A Baldi1, Daniel O Herzig1

  • 1Department of Surgery, Oregon Health and Science University, Portland, Oregon.

Clinics in Colon and Rectal Surgery
|August 6, 2025
PubMed
Summary
This summary is machine-generated.

The traditional surgery-first approach for colon cancer is evolving. New data support using neoadjuvant chemotherapy or immunotherapy before surgery for advanced colon cancer, followed by targeted therapies.

Keywords:
chemotherapycolon cancermicrosatellite instabilitynext-generation sequencing

More Related Videos

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

377
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.1K

Related Experiment Videos

Last Updated: Sep 12, 2025

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy
06:28

E-Patient Counseling Trial E-PACO: Computer Based Education versus Nurse Counseling for Patients to Prepare for Colonoscopy

Published on: August 1, 2019

8.4K
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

377
Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer
06:49

Orthotopic Implantation of Patient-Derived Cancer Cells in Mice Recapitulates Advanced Colorectal Cancer

Published on: February 10, 2023

2.1K

Area of Science:

  • Oncology
  • Surgical Oncology
  • Medical Oncology

Background:

  • The traditional surgery-first approach for colon cancer is being re-evaluated.
  • Advances in understanding tumor biology and measurable tumor features are driving changes in treatment paradigms.

Purpose of the Study:

  • To summarize contemporary data supporting tailored approaches to colon cancer treatment.
  • To highlight the integration of systemic therapy before or after surgical resection.

Main Methods:

  • Review of current clinical data and research findings.
  • Analysis of tumor characteristics guiding treatment decisions.

Main Results:

  • Certain tumor features now support neoadjuvant chemotherapy or immunotherapy for locally advanced colon cancer.
  • Targeted postoperative therapies can be effectively integrated into treatment plans.

Conclusions:

  • Contemporary data support a shift from the traditional surgery-first approach.
  • Tailored treatment strategies integrating systemic therapy and surgery are becoming standard for colon cancer management.