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Related Concept Videos

Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Metabolism-Mediated FGF5 Association with Stroke: Based on Mendelian Randomization and Bioinformatics Analysis.

Cong Xu1, Yonghong Xu2, Ling Gao3

  • 1School of Clinical Medicine, Dali University, Dali, Yunnan, 671000, People's Republic of China.

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Fibroblast growth factor 5 (FGF5) is a novel potential biomarker for stroke risk. Inflammatory factors and metabolites like GPE mediate stroke occurrence, offering new targets for intervention.

Keywords:
Mendelian randomizationinflammatory factorsmediation analysismetabolitestroke

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Area of Science:

  • Genetics and Bioinformatics
  • Metabolomics
  • Stroke Research

Background:

  • Stroke is a leading cause of death and disability globally.
  • The specific role of fibroblast growth factor 5 (FGF5) in stroke pathogenesis is not well understood.
  • Investigating potential causal links between inflammatory factors, metabolites, and stroke is crucial.

Purpose of the Study:

  • To evaluate the causal association between fibroblast growth factor 5 (FGF5) and stroke risk.
  • To explore the mediating role of metabolites in the relationship between inflammatory factors and stroke.
  • To investigate the expression and clinical relevance of FGF5 in stroke using multi-omics data.

Main Methods:

  • Bidirectional Mendelian randomization (MR) analysis using large-scale genetic data (FinnGen database).
  • Analysis of metabolite and inflammatory factor data from GWAS Catalog (EBI).
  • Exploration of FGF5 mRNA and protein expression (GEO database) and construction of a protein-protein interaction (PPI) network.

Main Results:

  • FGF5 showed a significant association with increased stroke risk (OR=1.052, P<0.01).
  • Mediation analysis suggested inflammatory factors influence stroke risk via metabolites, notably GPE.
  • FGF5 is implicated in cellular processes including epithelial cell proliferation and immune cell function (CD4+ T cells, M0 macrophages).

Conclusions:

  • FGF5 is identified as a novel potential biomarker for stroke risk.
  • Metabolites like GPE mediate stroke pathways influenced by inflammatory factors.
  • This study provides a basis for understanding stroke mechanisms and developing targeted interventions.