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Toxic Reactions: Overview01:26

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When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
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Drugs target macromolecules to modify ongoing cellular processes. Primary drug targets include receptors, ion channels, transporters, and enzymes.
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Related Experiment Video

Updated: Sep 12, 2025

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation
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ToxiTaRGET: a multi-omics resource for toxicant-responsive molecular targets.

Ravindra Kumar1,2, Tianyi Fu1,2, Prashant Kumar Kuntala3

  • 1Department of Developmental Biology, Washington University School of Medicine, St. Louis, MO 63108, USA.

Biorxiv : the Preprint Server for Biology
|August 6, 2025
PubMed
Summary

Early-life exposure to environmental toxicants like arsenic and lead can cause lasting molecular changes in mice. The ToxiTaRGET II Consortium created a resource to study these toxicant-induced genomic and epigenomic alterations.

Keywords:
ChromatinDNA methylationDatabaseDevelopmental Origins of Disease (DOHaD)Gene expressionHistone modificationsToxicoepigenetics

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Area of Science:

  • Environmental health
  • Toxicogenomics
  • Genomics and epigenomics

Background:

  • Environmental toxicants induce molecular alterations, increasing disease risk.
  • Understanding long-term impacts of early-life exposures is crucial.

Purpose of the Study:

  • To evaluate long-term transcriptome and epigenome impacts of early-life toxicant exposures in mice.
  • To create a comprehensive resource for studying these effects.

Main Methods:

  • The Toxicant Exposures and Responses by Genomic and Epigenomic Regulators of Transcription II (TaRGET II) Consortium conducted longitudinal studies.
  • Generated 3,607 multi-omics datasets from mice exposed to various toxicants.
  • Systematically identified and visualized molecular changes using the ToxiTaRGET platform.

Main Results:

  • Identified molecular signatures (gene expression, chromatin accessibility, DNA methylation) in response to toxicants.
  • Data spans multiple tissues, sexes, and life stages in mice.
  • The ToxiTaRGET platform provides an integrated view of these molecular changes.

Conclusions:

  • Early-life toxicant exposures cause significant and lasting molecular changes.
  • The ToxiTaRGET resource facilitates research in environmental health and toxicogenomics.
  • Provides a foundation for understanding disease links to environmental exposures.