Optimization of Silver Nanoparticle Dermal Patch Films for Enhanced Wound Healing: Formulation and Characterization...

Area of Science:

• Materials Science: Nanoparticle formulation and characterization.
• Biotechnology: Green synthesis of nanoparticles using plant extracts.
• Pharmacology: Dermal drug delivery systems for wound healing.

Background:

• Silver nanoparticles (AgNPs) possess potent antibacterial properties beneficial for wound healing.
• Dermal patch films (DPFs) offer an effective method for delivering active ingredients due to their adhesive nature.

Purpose of the Study:

• To formulate AgNPs into DPFs for enhanced wound healing applications.
• To optimize AgNP concentration within DPFs for improved efficacy and physical properties.

Main Methods:

• Green synthesis of AgNPs using Plantago major L. leaf extract.
• Fabrication of five DPF formulations (0-0.10% AgNPs) via solvent casting.
• Comprehensive evaluation including physical, chemical, and wound healing studies.

Main Results:

• All formulations yielded smooth, transparent films with favorable thickness and pH.
• Formulations F1-F4 exhibited excellent folding endurance; F4 and F5 showed the highest wound healing percentages.
• PXRD analysis indicated amorphous structures in F1-F4, while F5 retained crystalline AgNPs.

Conclusions:

• Green synthesized AgNPs in DPFs significantly improved physical characteristics, particularly in formulations F1-F4.
• Formulation F4 (0.05% AgNPs) demonstrated the highest wound healing efficacy.
• The study identifies F4 as the most promising DPF formulation for advanced wound healing.