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Related Experiment Video

Updated: May 13, 2026

Assessing Cortical Cerebral Microinfarcts on High Resolution MR Images

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Published on: November 20, 2015

Characterizing the association between complement-mediated TMA and cognitive dysfunction using MRI and neurocognitive

Pauline K Kosalka¹, Fahad Hannan², Jeff Hamilton²

¹Division of Nephrology, Department of Medicine, Western University, London, ON, Canada.

Blood Vessels, Thrombosis & Hemostasis

|August 6, 2025

Summary

Patients with complement-mediated thrombotic microangiopathy (CM-TMA) show persistent white matter abnormalities and neurocognitive deficits, including impaired memory and concentration, even after treatment. Further research is needed to understand these long-term effects.

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Published on: November 22, 2024

Area of Science:

Neuroscience
Hematology
Complement System Biology

Background:

Complement-mediated thrombotic microangiopathy (CM-TMA) is a severe condition linked to complement pathway defects, often causing kidney and brain issues.
Long-term neurocognitive consequences of CM-TMA remain unclear, necessitating further investigation.

Purpose of the Study:

To evaluate long-term neurocognitive complications in CM-TMA patients using MRI and neurocognitive tests.
To compare cerebral white matter changes and cognitive function in CM-TMA patients versus healthy controls.

Main Methods:

Included seven adult CM-TMA patients in remission (treated with C5 complement blockade) and six healthy controls.
Utilized serial MRI scans (standard-of-care and quantitative) and neurocognitive testing over 12 months.
Assessed microstructural changes in cerebral white matter and cognitive performance.

Main Results:

CM-TMA patients exhibited increased white matter signal intensity compared to controls.
Patients reported higher rates of depression and demonstrated neurocognitive dysfunction, including impaired concentration, short-term memory, and verbal memory.
These neurological and cognitive impairments persisted up to 12 months post-initial assessment.

Conclusions:

Previous CM-TMA is associated with significant, non-specific cerebral white matter abnormalities.
Impaired memory and concentration are notable long-term neurocognitive complications in CM-TMA survivors.
Larger longitudinal studies are required to fully elucidate the neurocognitive sequelae of CM-TMA.