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A Case Report of Calciphylaxis.

Kim Hoang1, Tien Lu2, Alex Dang2

  • 1University of California, Irvine, School of Medicine, Irvine, CA.

Journal of Education & Teaching in Emergency Medicine
|August 6, 2025
PubMed
Summary

Calciphylaxis, a rare condition often seen in end-stage renal disease patients, causes painful wounds. This case highlights its clinical features and treatment strategies for this life-threatening illness.

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Area of Science:

  • Nephrology
  • Dermatology
  • Vascular Medicine

Background:

  • Calciphylaxis is a rare, severe condition with high mortality.
  • It is poorly understood but associated with significant morbidity.
  • Patients with end-stage renal disease (ESRD) are particularly at risk.

Purpose of the Study:

  • To present a case of calciphylaxis in a patient with ESRD.
  • To review the clinical presentation of calciphylaxis.
  • To discuss potential treatment strategies for this condition.

Main Methods:

  • Case report of a 44-year-old male with ESRD on dialysis.
  • Detailed physical examination findings of chronic, painful leg wounds.
  • Hospital admission for intravenous antibiotics, wound care, and specialist consultation.

Main Results:

  • The patient presented with ulcerated, bilateral anterior leg wounds with eschar and purulent drainage.
  • Diagnosis of calciphylaxis was suspected based on clinical presentation.
  • Initiation of comprehensive medical and wound care management.

Conclusions:

  • Calciphylaxis requires prompt recognition and multidisciplinary management.
  • Early intervention with antibiotics and wound care is crucial.
  • Further research is needed to elucidate pathophysiology and optimize treatment for calciphylaxis.