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Evaluation of a patient decision aid for Japanese women with BRCA1/2 pathogenic variants: A preliminary study

Megumi Okawa^1,2, Naoko Arimori¹

¹Graduate School of Health Sciences, Niigata University, Niigata, Japan.

Japan Journal of Nursing Science : JJNS

|August 6, 2025

Abstract

Aim:

This study aimed to evaluate a decision aid for Japanese women (J-DA) with BRCA1/2 pathogenic variants for supporting breast and ovarian cancer management decisions.

Methods:

This study used a pre- and post-intervention design. The participants included Japanese women with BRCA1/2 pathogenic variants who needed to make a decision regarding breast and ovarian cancer management options.

Results:

All 25 participants completed the pre- and posttests. There was a significant reduction in the decisional conflict scale and a significant increase in the knowledge score. Significant improvements were identified in the decisional conflict scale score (g = 0.60, p = .002) and knowledge score (g = -1.44, p < .001). Four weeks post-intervention, 96% of the participants had made a decision regarding the management options for breast or ovarian care.

Conclusions:

The findings suggest that the decision aid (J-DA) positively supported the decision-making of the Japanese women with BRCA1/2 pathogenic variants. As this study apparently represents the first evaluation of a decision aid for this population, subsequent studies are anticipated to further confirm its clinical applicability and utility.

Keywords:

BRCA1 and BRCA2 breast neoplasms decision support techniques decision‐making hereditary breast and ovarian cancer syndrome ovarian neoplasms

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