Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Working Memory01:24

Working Memory

446
Working memory refers to a combination of components, including short-term memory and attention, that allow an individual to hold information temporarily as we perform cognitive tasks. It is an essential cognitive function that enables the execution of complex tasks such as problem-solving, comprehension, and reasoning. Unlike short-term memory, which simply involves the storage of information for a brief period, working memory involves the active manipulation and processing of this...
446
Role of Cerebellum and Prefrontal Cortex in Memory01:14

Role of Cerebellum and Prefrontal Cortex in Memory

577
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
577
Auditory Pathway01:15

Auditory Pathway

5.8K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
5.8K
Auditory Perception01:17

Auditory Perception

582
The auditory system is essential for sound perception, utilizing various critical structures. When sound waves enter the outer ear, they travel through the ear canal and cause the eardrum to vibrate. These vibrations are then transmitted to the middle ear, where three tiny bones – the malleus, incus, and stapes – amplify the sound. This amplification is crucial, as it ensures that the sound vibrations are strong enough to be conveyed to the inner ear. These vibrations then reach the...
582

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Automated Behavior Analysis in the Novel Object Recognition Test.

Neurocomputing·2026
Same author

Gateway to the study of the amygdala and emotion.

Cerebral cortex (New York, N.Y. : 1991)·2024
Same author

Maternal choline supplementation modulates cognition and induces anti-inflammatory signaling in the prefrontal cortices of adolescent rats exposed to maternal immune activation.

Brain, behavior, & immunity - health·2024
Same author

Altered prefrontal and cerebellar parvalbumin neuron counts are associated with cognitive changes in male rats.

Experimental brain research·2024
Same author

Maternal choline supplementation in neurodevelopmental disorders: mechanistic insights from animal models and future directions.

Nutritional neuroscience·2024
Same author

Adolescent treadmill exercise enhances hippocampal brain-derived neurotrophic factor (BDNF) expression and improves cognition in autism-modeled rats.

Physiology & behavior·2024
Same journal

Metabolic Brain Network Reorganization in Temporal Lobe Epilepsy With Aware or Impaired Awareness Seizures.

Journal of integrative neuroscience·2026
Same journal

Longitudinal Reorganization of Local Brain Activity Following Acute Basal Ganglia Infarction: Combined Metrics of Amplitude and Dynamics Reveal Neural Substrates Underlying Motor Recovery.

Journal of integrative neuroscience·2026
Same journal

The Neuroprotective Role of a Caspase-1 Inhibitor Against Apoptosis via Inhibition of Glial Hyperactivation in a Mouse Model of Epilepsy.

Journal of integrative neuroscience·2026
Same journal

Understanding Sleep and Memory in the Avian Brain.

Journal of integrative neuroscience·2026
Same journal

Tea Polyphenols Protect the Blood-Brain Barrier Structure in the Hippocampus of Early Diabetic Mice by Inhibiting the AGEs-RAGE Pathway.

Journal of integrative neuroscience·2026
Same journal

Single-Cell and Integrative Analyses Uncover Therapeutic Potential of RFX1-Mediated Cuproptosis in PitNETs.

Journal of integrative neuroscience·2026
See all related articles

Related Experiment Video

Updated: Sep 12, 2025

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

7.0K

Inactivation of Dorsolateral Prefrontal Cortex During Auditory Working Memory.

Bethany Plakke1, Katryna Skye Kevelson2, Charles Leyens3

  • 1Department of Psychological Sciences, Kansas State University, Manhattan, KS 66502, USA.

Journal of Integrative Neuroscience
|August 6, 2025
PubMed
Summary
This summary is machine-generated.

Dorsolateral prefrontal cortex (DLPFC) inactivation did not impair auditory working memory (WM) in macaques. These findings suggest the DLPFC and ventrolateral prefrontal cortex (VLPFC) have distinct roles in auditory WM.

Keywords:
auditory discriminationlesionprefrontal cortexvocalizationworking memory

More Related Videos

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.3K
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.9K

Related Experiment Videos

Last Updated: Sep 12, 2025

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat
09:43

Reversible Cooling-induced Deactivations to Study Cortical Contributions to Obstacle Memory in the Walking Cat

Published on: December 11, 2017

7.0K
Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity
10:43

Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

Published on: July 1, 2014

15.3K
Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

18.9K

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience

Background:

  • The dorsolateral prefrontal cortex (DLPFC) is implicated in working memory (WM), particularly visuospatial WM.
  • Evidence for its role in auditory WM is mixed, with some studies suggesting involvement and others pointing to the ventrolateral prefrontal cortex (VLPFC).

Purpose of the Study:

  • To investigate the role of the DLPFC in auditory working memory.
  • To compare the effects of DLPFC inactivation with known effects of VLPFC inactivation on auditory WM performance.

Main Methods:

  • Transient inactivation of the DLPFC (areas 46v, 46d, and 9) in rhesus macaques using cortical cooling.
  • Permanent ibotenic acid lesions of the DLPFC followed by behavioral assessment of auditory WM task performance.

Main Results:

  • Cortical cooling inactivation of the DLPFC did not significantly impair auditory WM performance.
  • Ibotenic acid lesions of the DLPFC also did not significantly alter auditory WM performance.
  • Transient inactivation led to increased gaze aversion in one subject, possibly indicating attention or motivation deficits.

Conclusions:

  • The DLPFC does not appear to play a critical role in auditory working memory performance.
  • These findings suggest a functional dissociation between the DLPFC and VLPFC in auditory WM, with the VLPFC potentially having a more significant role.