Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Blood-brain Barrier00:49

The Blood-brain Barrier

48.7K
Overview
48.7K
Cranial and Spinal Meninges01:19

Cranial and Spinal Meninges

1.7K
The cranial and spinal meninges are complex protective structures surrounding the central nervous system (CNS), consisting of the brain and spinal cord. These meninges consist of the dura mater, the arachnoid mater, and the pia mater. They protect the CNS, provide structural support, and aid in circulating cerebrospinal fluid (CSF).
Cranial Meninges
These meningeal layers cover the cranium. The dura mater is the outermost layer of cranial meninges. It is a thick and durable membrane of dense...
1.7K
Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

3.9K
The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
3.9K
Blinding01:11

Blinding

2.6K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.6K
Glial Cells01:04

Glial Cells

88.9K
Overview
88.9K
Nervous Tissue: Glial Cells01:31

Nervous Tissue: Glial Cells

3.8K
Glia, or neuroglia, are vital support cells that assist neurons in their functions. The term "glia" originates from the Greek word for "glue," reflecting their role in holding the nervous system together. These cells can be categorized into six types: four in the central nervous system (CNS) and two in the peripheral nervous system (PNS).
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
3.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Individualised stimlation parameters in deep brain stimulation for Parkinson's disease based on disease phenotype and brain connectivity: protocol for a randomised feasibility study in a tertiary care centre (iDBS trial).

BMJ open·2026
Same author

The Role of a Social Worker in the Deep Brain Stimulation Preoperative Evaluation: The DBS-FACTS Screening Tool.

Movement disorders clinical practice·2025
Same author

Visor flap: A solution for the reconstruction of large skin defects on the frontal and parietal parts of the skull.

Head & neck·2024
Same author

Long-Term Longitudinal Course of Cognitive and Motor Symptoms in Patients With Cerebral Small Vessel Disease.

Neurology·2024
Same author

Translation and Validation of the Dutch Version of the Sun Exposure and Protection Index.

Dermatology (Basel, Switzerland)·2023
Same author

Translating Evidence to Advanced Parkinson's Disease Patients: A Systematic Review and Meta-Analysis.

Movement disorders : official journal of the Movement Disorder Society·2021

Related Experiment Video

Updated: Sep 12, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.6K

[Brain and blisters: a special bond].

Floor Lijten1, Amée Wolters2, Rianne Esselink3

  • 1Radboudumc, Department of Dermatology, Nijmegen, the Netherlands.

Tijdschrift Voor Gerontologie En Geriatrie
|August 6, 2025
PubMed
Summary
This summary is machine-generated.

Bullous pemphigoid (BP), an autoimmune skin disease, is linked to neurodegenerative disorders like Parkinson's disease. This case highlights BP preceding Parkinson's symptoms, suggesting a potential diagnostic clue.

Keywords:
Neurodegenerative diseaseBullous pemphigoidParkinson’s diseas

More Related Videos

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.1K
Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury
05:19

Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury

Published on: October 18, 2024

835

Related Experiment Videos

Last Updated: Sep 12, 2025

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.6K
A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo
11:17

A Suction Blister Protocol to Study Human T-cell Recall Responses In Vivo

Published on: August 11, 2018

12.1K
Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury
05:19

Evaluation of Blood-Brain Barrier Breakdown in a Mouse Model of Mild Traumatic Brain Injury

Published on: October 18, 2024

835

Area of Science:

  • Dermatology
  • Neuroimmunology
  • Autoimmune diseases

Background:

  • Bullous pemphigoid (BP) is an autoimmune blistering skin disease.
  • BP involves autoantibodies against hemidesmosomal proteins BP180 and BP230.
  • An association exists between BP and neurodegenerative disorders, notably Parkinson's disease.

Purpose of the Study:

  • To investigate the clinical significance of the association between bullous pemphigoid and Parkinson's disease.
  • To present a case where bullous pemphigoid preceded the clinical manifestation of Parkinson's disease.

Main Methods:

  • Case report detailing a patient with diagnosed bullous pemphigoid.
  • Clinical follow-up noting the development of Parkinson's disease symptoms.
  • Neurological assessment to confirm the diagnosis of Parkinson's disease.

Main Results:

  • The patient presented with bullous pemphigoid.
  • During follow-up, the patient developed clinical features suggestive of Parkinson's disease.
  • Neurological analysis indicated the patient likely had long-standing Parkinson's disease.

Conclusions:

  • This case suggests that bullous pemphigoid may precede the overt clinical diagnosis of Parkinson's disease.
  • The findings underscore the importance of recognizing the link between BP and neurodegenerative conditions for healthcare professionals.
  • Further research is warranted to elucidate the mechanisms underlying this association.