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Impact of Sleep Disorders on Cognitive Function in Stroke: A Systematic Review and Meta-analysis
Yingqiao Wang1, Leyao Han1, Zongyan Man2
1School of Nursing, Lanzhou University, Lanzhou, China.
Sleep disorders significantly increase the risk of cognitive impairment in stroke patients. This risk is amplified in older individuals, highlighting the need for targeted interventions.
Area of Science:
- Neurology
- Sleep Medicine
- Cognitive Science
Background:
- Sleep disorders negatively impact stroke recovery, affecting physiological function, readmission rates, and mortality.
- The precise impact of sleep disorders on cognitive function post-stroke remains inconsistent.
- This study investigates the link between sleep disorders and cognitive impairment in stroke survivors.
Purpose of the Study:
- To determine the effect of sleep disorders on cognitive functions in stroke patients.
- To explore the relationship between specific types of sleep disorders and cognitive deficits.
- To provide evidence for better management strategies for stroke patients with sleep disturbances.
Main Methods:
- A systematic review and meta-analysis of studies from multiple databases (PubMed, Cochrane, Web of Science, Embase, CBM, CNKI, Wanfang, VIP).
- Inclusion of 6 longitudinal and 10 cross-sectional studies involving 5,779 patients.
- Statistical analysis using Revman 5.3 to combine odds ratios (ORs) and standardized mean differences (SMDs), with heterogeneity and sensitivity analyses.
Main Results:
- Both longitudinal and cross-sectional studies indicated that stroke patients with sleep disorders are significantly more likely to experience cognitive impairment (ORs ranging from 2.35 to 2.62).
- High heterogeneity in cross-sectional studies was addressed, with results remaining consistent after data refinement.
- Advanced age was identified as a significant factor exacerbating the negative cognitive effects of sleep disorders in stroke patients.
Conclusions:
- Sleep disorders are confirmed as associated factors contributing to cognitive impairment in stroke survivors.
- The negative impact of sleep disorders on cognition in stroke patients is more pronounced with increasing age.
- Addressing sleep disorders in stroke patients, particularly older adults, is crucial for mitigating cognitive decline.
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