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Long-Term Outcomes and Predictors in Cancer-Related Stroke Using the Linked Data Set.

Tae Jung Kim1,2, Ji Sung Lee3, Mi Sun Oh4

  • 1Department of Neurology Seoul National University College of Medicine Seoul Korea.

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|August 6, 2025
PubMed
Summary
This summary is machine-generated.

Long-term outcomes for cancer-related stroke are poor, with high mortality rates. Key factors influencing survival include patient age, stroke severity, discharge treatment, and specific cancer types.

Keywords:
cancerischemic strokelong‐term outcomes

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Area of Science:

  • Neurology
  • Oncology
  • Epidemiology

Background:

  • Limited data exists on long-term prognostic factors for cancer-related stroke.
  • Cancer-related stroke significantly impacts patient outcomes and survival.

Purpose of the Study:

  • To evaluate long-term outcomes in patients with cancer-related stroke.
  • To identify prognostic factors associated with mortality and adverse events in this population.

Main Methods:

  • Utilized a linked dataset combining claims and registry data for 690 cancer-related stroke patients (2008-2014).
  • Assessed long-term mortality, major bleeding (intracerebral hemorrhage, gastrointestinal bleeding), and recurrent ischemic stroke.
  • Analyzed clinical factors including vascular risk factors, acute stroke management, and cancer types.

Main Results:

  • Over a median of 1.7 years, 58.1% of patients died.
  • Old age, stroke severity, anticoagulation at discharge, and specific cancers (pancreatic, hepatobiliary, lung) were linked to increased long-term mortality.
  • Major bleeding occurred in 6.1% and recurrent ischemic stroke in 12.9% of patients.

Conclusions:

  • Cancer-related stroke is associated with poor long-term prognosis.
  • Treatment strategies at discharge and the type of cancer are critical determinants of long-term survival.