Correlation Between CRT Response and Patient-Regret Scores in Patients With Heart Failure With Reduced Ejection
Aritra Paul1, Joe Demian1, Niraj Varma1
1Cardiac Electrophysiology and Pacing Section, Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, Ohio, USA.
Journal of Cardiovascular Electrophysiology
|August 6, 2025
Summary
Patients with heart failure with reduced ejection fraction (HFrEF) undergoing cardiac resynchronization therapy (CRT) generally do not regret the procedure, regardless of CRT response. Device implantation satisfaction remains high, irrespective of echocardiographic improvements.
Area of Science:
- Cardiology
- Medical Devices
- Patient Outcomes
Background:
- The relationship between cardiac resynchronization therapy (CRT) effectiveness and patient satisfaction is not well understood.
- Assessing patient perception of CRT is crucial for understanding the overall impact of the therapy.
Purpose of the Study:
- To investigate the correlation between CRT response and patient-reported outcomes using a decision regret scale (DRS).
- To evaluate patient satisfaction after CRT implantation in heart failure with reduced ejection fraction (HFrEF) patients.
Main Methods:
- 150 HFrEF patients undergoing CRT implantation were assessed using the DRS at 6 months post-procedure.
- CRT response was determined echocardiographically (LVEF improvement >5%, LVESV reduction >10%).
- Patients were unaware of their CRT response status when completing the DRS.
Main Results:
- No patients reported significant regret regarding CRT device implantation.
- No statistically significant difference in DRS scores was observed between CRT responders and non-responders.
- Mean LVEF was significantly higher in responders (43%) versus non-responders (27%) (p<0.001).
Conclusions:
- Patients with HFrEF undergoing CRT report overwhelmingly positive feelings about their decision, irrespective of CRT response.
- Significant cardiac remodeling or CRT response did not influence patient satisfaction with the decision to undergo CRT implantation.
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