Variables related to locoregional and distant recurrence in esophageal cancer
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View abstract on PubMed
Summary
This summary is machine-generated.Tumor stage, location, and histology predict esophageal cancer recurrence after surgery. Squamous cell carcinoma increases locoregional recurrence but lowers distant metastasis risk, while multimodal therapy benefits stage III patients.
Area Of Science
- Gastroenterology
- Surgical Oncology
- Cancer Research
Background
- Esophageal cancer is aggressive with high recurrence and mortality rates post-surgery.
- Identifying recurrence predictors is vital for personalized esophageal cancer treatment.
- Current adjuvant therapies offer limited impact on recurrence post-esophagectomy.
Purpose Of The Study
- To identify pretreatment and treatment-related factors associated with recurrence in esophageal cancer patients.
- To analyze disease-free survival and recurrence patterns following esophagectomy.
- To evaluate the impact of tumor characteristics and multimodal therapy on esophageal cancer outcomes.
Main Methods
- Retrospective analysis of 2,057 stage I-III esophageal cancer patients undergoing esophagectomy (2000-2025).
- Utilized the Fundação Oncocentro de São Paulo (FOSP) database for clinical, histological, and treatment data.
- Employed Cox proportional hazards and Fine-Gray models to assess survival and recurrence.
Main Results
- Advanced tumor stage, middle/upper esophagus location, and rare histological subtypes predicted worse disease-free survival.
- Multimodal therapy improved disease-free survival in stage III tumors.
- Squamous cell carcinoma linked to higher locoregional recurrence but lower distant metastasis; high tumor grade increased distant recurrence risk.
Conclusions
- Tumor stage, location, and histology are key predictors of esophageal cancer recurrence post-surgery.
- Histology significantly impacts recurrence patterns: squamous cell carcinoma vs. adenocarcinoma.
- Multimodal therapy shows a protective effect for stage III esophageal cancer.
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