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Updated: Sep 12, 2025

Cone Beam Intraoperative Computed Tomography-based Image Guidance for Minimally Invasive Transforaminal Interbody Fusion
Published on: August 6, 2019
Failure to Reach Early MCID in ACDF Patients
Andrea M Roca1, Fatima N Anwar, Ishan Khosla
1Department of Orthopaedic Surgery, Rush University Medical Center, Chicago, IL.
Study Design:
Retrospective cohort study.
Objective:
The objective of this study is to identify factors of early minimal clinically important difference (MCID) failure after anterior cervical discectomy and fusion (ACDF).
Summary Of Background Data:
Research on predictors of MCID failure after ACDF is limited.
Methods:
Patients undergoing primary, elective ACDF were selected from a single spine surgeon database. Demographics, perioperative characteristics, and Visual Analog Scale Neck (VAS-N), VAS-Arm (VAS-A), Neck Disability Index (NDI), patient-reported outcome measurement information system-physical function (PROMIS-PF), 12-item Short Form (SF-12) Mental Component Score (MCS), SF-12 Physical Component Score (SF-12 PCS), and 9-item Patient Health Questionnaire (PHQ-9) scores were collected. A 2-step multivariable logistic regression was performed to determine predictors of MCID failure.
Results:
A total of 240 patients were included. Preoperative VAS-N and diagnosis of foraminal stenosis were significant positive predictors of failure. Workers' compensation (WC) was a negative predictor, whereas smoker status and preoperative VAS-A were positive predictors. Preoperative PROMIS-PF, preoperative SF-12 PCS/MCS, and postoperative day 0 narcotic consumption were negative predictors, and length of stay was a positive predictor.
Conclusion:
The variations in follow-up compliance among spine surgery patients highlight the importance of identifying predictors of early MCID failure rates to avoid less than favorable patient experiences. In our study, we identified data to suggest that positive predictors of early failure may be associated with higher preoperative neck pain, smoker status, and longer length of stay. In comparison, negative predictors are related to WC insurance, better preoperative physical function and mental health, or postoperative narcotic consumption.

