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Updated: Sep 8, 2025

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus KSHV
Published on: September 14, 2010
Spontaneous Regression of Oral Kaposi Sarcoma in an HIV Negative Male
Isabella C Galina1, Selenne Romero-Servin2, Kevin Arce3
1Division of Oral and Maxillofacial Surgery, School of Dentistry, University of Minnesota, Minneapolis, USA.
Abstract:
Oral Kaposi sarcoma is a slowly progressing, HHV-8 related angioproliferative disorder strongly associated with immunosuppression. Regression can occur with treatment. We present a 49-year-old HIV-seronegative Caucasian male individual with two rapidly enlarging OKS lesions that spontaneously regressed and completely resolved without treatment after a few months. The individual was under treatment with valacyclovir for herpes simplex infection and was receiving emtricitabine/tenofovir for HIV pre-exposure prophylaxis. Only the mandibular lesion was biopsied, revealing classic endothelial spindle cell proliferation with formation of slit-like spaces and multiple newly formed vessels. Nuclear HHV-8 was immunohistochemically confirmed. Serologic tests prior to and after the development of OKS did not reveal HIV infection. Emtricitabine/tenofovir prophylactic treatment may have contributed to the remission and resolution.
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