HcN13, a Fibroblast Growth Factor Binding Protein, Is Associated with Shell Formation in Hyriopsis cumingii
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.A novel Fibroblast Growth Factor Binding Protein (FGF-BP), HcN13, identified in mussels, is crucial for shell formation and biomineralization. Its suppression destroys shell structures, highlighting its essential role in invertebrates.
Area Of Science
- Marine Biology
- Biochemistry
- Biomineralization
Background
- Fibroblast growth factor binding proteins (FGF-BPs) are known regulators of FGF signaling in vertebrates.
- Their role in invertebrate biomineralization, particularly in mollusk shell formation, remains largely unexplored.
Purpose Of The Study
- To identify and characterize a novel FGF-BP in the mollusk Hyriopsis cumingii.
- To investigate the function of this protein in shell matrix formation and biomineralization.
Main Methods
- Gene identification and sequence analysis of HcN13 from Hyriopsis cumingii.
- Quantitative real-time PCR and in situ hybridization for expression analysis.
- In vivo suppression of HcN13 and in vitro crystal formation assays.
Main Results
- HcN13, a novel FGF-BP family member, is expressed in the mollusk mantle, specifically in nacreous layer-forming cells.
- Suppression of HcN13 led to the destruction of shell prisms and nacre tablets.
- HcN13 expression correlates with both normal and disordered pearl nacre deposition.
Conclusions
- HcN13 is essential for mollusk shell formation and biomineralization, acting as a modulator of signaling pathways.
- This study reveals the presence and critical function of FGF-BPs in invertebrate biomineralization for the first time.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
Filopodia are thin, actin-rich cellular protrusions that play an important role in many fundamental cellular functions. They vary in their occurrence, length, and positioning in different cell types, suggesting their diverse roles.
Their main function is to guide migrating cells during normal tissue morphogenesis or cancer metastasis by recognizing and making initial contacts with the extracellular matrix. However, they can also act as stationary cell anchors or help to establish communication...
Cytoskeletal filaments are polymeric forms of smaller protein subunits. However, individual cytoskeletal filaments may easily disassemble or associate with other similar filaments to form rigid structures. Microfilaments, made of actin monomers, rely on actin-binding proteins to form bundles and create networks of individual actin filaments. Microtubules rely on microtubule-associated proteins (MAPs) to form sturdy cylindrical structures. However, the proteins involved in forming complex...