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Ultrasensitive Detection of Biomarkers by Using a Molecular Imprinting Based Capacitive Biosensor

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Published on: February 16, 2018

Fano Resonance Sensor Based on Microhole Array Waveguides for Ultrasensitive Label-Free Biosensing.

Biao Zhao^1,2,3, Aoqun Jian^1,2, Min Li^1,2

¹Shanxi Key Laboratory of Micro-Nano Sensors & Artificial Intelligence Perception, College of Electronic Information and Optical Engineering, Taiyuan University of Technology, Taiyuan 030024, China.

|August 6, 2025

Summary

This summary is machine-generated.

A novel Fano resonance biosensing platform using photon-plasmon coupling enhances surface plasmon resonance (SPR) sensor sensitivity for trace biomolecule detection. This high-performance sensor achieves significant improvements in sensitivity and figure of merit.

Keywords:

Fano resonance biosensor high sensitivity microhole array waveguide surface plasmon resonance

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Area of Science:

Nanotechnology
Biosensing
Optics

Background:

Surface plasmon resonance (SPR) sensors are crucial for detecting trace biomolecules.
Enhancing SPR sensor sensitivity is vital for advanced diagnostics.
Existing Fano-type sensors have limitations in sensitivity and figure of merit.

Purpose of the Study:

To develop an innovative Fano resonance biosensing platform for enhanced SPR sensitivity.
To improve light-matter interaction through photon-plasmon coupling.
To create a cost-effective and high-performance biosensor for biomolecule detection.

Main Methods:

Fabrication of a sensor comprising a poly(methyl methacrylate) (PMMA) microhole array waveguide, MY-131-MC dielectric layer, and silver plasmonic layer.
Utilizing photon-plasmon coupling to enhance Fano resonance.
Modulating spatial coupling between photonic field and microhole membrane for electromagnetic field overlap.

Main Results:

Achieved ultrahigh sensitivity of 56.24 μm/RIU for refractive index (RI) detection, an 11.4-fold improvement.
Elevated figure of merit (FOM) to 2998.94 RIU^-1, surpassing conventional SPR sensors by two orders of magnitude.
Demonstrated a limit of detection (LOD) of 81.8 pg/mL for carcinoembryonic antigen (CEA) detection with high selectivity, repeatability, and stability.

Conclusions:

The developed Fano resonance biosensing platform offers a significant advancement in SPR sensor sensitivity.
The photon-plasmon coupling enhancement strategy provides a novel approach for high-performance biosensing.
This simple, cost-effective method presents a promising strategy for sensitive and selective detection of biomarkers.