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Evaluation of transfusion reactions in patients following transfusion of blood components containing antibodies to HLA class I - An attempt to prevent TRALI in patients.

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Streamlined Purification of Plasmid DNA From Prokaryotic Cultures
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A place for plasmapheresis.

Lise Sofie H Nissen-Meyer1

  • 1Department of Immunology, Oslo University Hospital, Oslo, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
|August 6, 2025
PubMed
Summary
This summary is machine-generated.

Increasing demand for source plasma necessitates encouraging voluntary, non-remunerated plasma donation. Blood centers are boosting plasmapheresis to meet needs and retain donors, adapting strategies for sustainable plasma collection.

Keywords:
Blood centerPlasma donorPlasmapheresis

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Area of Science:

  • Biomedical Science
  • Public Health
  • Blood Transfusion Medicine

Background:

  • Europe faces increasing demand for source plasma for plasma-derived medical products.
  • A gap exists between plasma production and utilization, raising ethical and medical concerns.
  • National strategies increasingly focus on encouraging non-remunerated voluntary plasma donation.

Purpose of the Study:

  • To discuss the necessary mindset shift for increasing plasmapheresis activity within existing frameworks.
  • To highlight strategies blood centers are employing to boost plasma donation.
  • To emphasize the importance of retaining whole blood donors through plasma donation.

Main Methods:

  • Commentary based on observations and practices at Oslo Blood Center.
  • Analysis of current trends in blood center operations and donor management.
  • Review of national plasma strategy documents and European initiatives.

Main Results:

  • Blood centers are increasing plasmapheresis to enhance plasma collection and donor retention.
  • Encouraging whole blood donors to also donate plasma maintains donor engagement.
  • A shift in mindset is crucial for optimizing plasmapheresis within current operational structures.

Conclusions:

  • Adapting donor engagement strategies, like encouraging concurrent plasma donation, is key to meeting rising plasma demand.
  • Increased plasmapheresis activity is vital for the sustainable production of plasma-derived therapies.
  • International collaboration and discussion are needed to address ethical and medical questions surrounding source plasma.