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Updated: Sep 12, 2025
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Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography
Published on: October 28, 2020
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Right Ventricular Dysfunction and Adverse Clinical Outcomes in Peripartum Cardiomyopathy: A Meta-Analysis.
Ali A Khan1, Fayez H Fayad1, Chan W Kim2
1Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
JACC. Advances
|August 6, 2025
Summary
Right ventricular dysfunction in peripartum cardiomyopathy (PPCM) is linked to poorer outcomes. Patients with RV dysfunction face a lower chance of left ventricular recovery and a higher risk of major adverse events.
Area of Science:
- Cardiology
- Cardiovascular Imaging
- Heart Failure Research
Background:
- Prognostic significance of right ventricular (RV) dysfunction in peripartum cardiomyopathy (PPCM) is debated.
- Existing studies show inconsistent findings regarding RV dysfunction's impact on PPCM outcomes.
Purpose of the Study:
- To assess the association between RV dysfunction at diagnosis and left ventricular (LV) systolic function recovery in PPCM.
- To evaluate the link between RV dysfunction and major adverse clinical outcomes in PPCM patients.
Main Methods:
- A meta-analysis of five studies involving 472 patients (117 with RV dysfunction) was conducted.
- RV dysfunction was identified using echocardiography or cardiac MRI criteria.
- Primary outcomes included LV systolic function recovery and major adverse clinical events; random-effect models were used for pooled analysis.
Main Results:
- RV dysfunction significantly decreased the likelihood of LV systolic function recovery (OR: 0.39; P < 0.001).
- Patients with RV dysfunction were four times more likely to experience adverse clinical outcomes (OR: 4.19; P < 0.001).
- Follow-up ranged from 6.8 to 42.6 months across studies.
Conclusions:
- RV dysfunction at diagnosis is a significant predictor of adverse outcomes in PPCM.
- Early identification of RV dysfunction may guide management strategies for PPCM patients to improve prognosis.
Keywords:
adverse clinical outcomesleft ventricular recoverymeta-analysisperipartum cardiomyopathyprognostic factorsright ventricular dysfunctionMore Related Videos
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