Exposure to persistent organic pollutants and sarcopenia: Revealing associations, mediated modifications, and potential mechanisms
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
View abstract on PubMed
Summary
This summary is machine-generated.Persistent organic pollutants (POPs) impact sarcopenia risk. Organochlorine pesticides (OCPs) increase risk, while polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) decrease it, with inflammation playing a mediating role.
Area Of Science
- Environmental Health
- Gerontology
- Toxicology
Background
- Sarcopenia is a significant global health concern.
- Identifying risk factors for sarcopenia is crucial for effective prevention strategies.
- The impact of persistent organic pollutants (POPs) on sarcopenia is not well understood.
Purpose Of The Study
- To investigate the association between exposure to a mixture of POPs and sarcopenia.
- To explore the mediating roles of inflammation and oxidative stress in this relationship.
- To identify potential molecular targets involved in POPs-induced sarcopenia.
Main Methods
- Analysis of 2106 participants from the National Health and Nutrition Examination Survey (NHANES).
- Assessment of 19 POPs (PCBs, OCPs, PFAS, PBDEs) and sarcopenia status.
- Application of WQS regression, BKMR, and mediation analysis to examine mixed effects and pathways.
Main Results
- Mixed POPs exposure, particularly PCBs and PBDEs, showed an inverse association with sarcopenia risk.
- Organochlorine pesticides (OCPs) exposure was positively associated with increased sarcopenia risk.
- Inflammation mediated the effects of specific POPs (PCB187, ppDDE) on sarcopenia.
Conclusions
- OCPs are linked to higher sarcopenia risk, while PCBs and PBDEs are associated with lower risk.
- PFAS did not show a significant association with sarcopenia in this study.
- CDKN1A, NFKBIA, CSF1R, and TFRC may be key molecular targets in POPs' influence on sarcopenia.
Contact us if these videos are not relevant.
Contact us if these videos are not relevant.
Related Concept Videos
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...